{"id":"W4396674492","doi":"10.1021/acs.jafc.3c08791","title":"Molecular Mechanistic Insights into Dipeptidyl Peptidase-IV Inhibitory Peptides to Decipher the Structural Basis of Activity","year":2024,"lang":"en","type":"article","venue":"Journal of Agricultural and Food Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Natural Science Foundation of China","keywords":"Tripeptide; Chemistry; Peptide; Dipeptidyl peptidase; Biochemistry; Inhibitory postsynaptic potential; Quantitative structure–activity relationship; Stereochemistry; Oligopeptide; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001075113,0.0002115594,0.0003881668,0.00006210296,0.00009164819,0.00006447307,0.0001104639,0.0001045218,0.00008195538],"category_scores_gemma":[0.00008249317,0.0001005708,0.0003526814,0.0003476519,0.00009048047,0.0001450376,0.00006422352,0.0003879181,0.000003050641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007979913,"about_ca_system_score_gemma":0.00006483797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006234164,"about_ca_topic_score_gemma":0.000005028685,"domain_scores_codex":[0.998773,0.00002935394,0.0004067835,0.0001943508,0.000437524,0.0001589897],"domain_scores_gemma":[0.9990833,0.0000699646,0.0001823098,0.0001300685,0.0002793252,0.0002550387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005495231,0.00004395049,0.00005272936,0.0003530109,0.0003251966,0.0000491707,0.0006143465,0.00002903311,0.996299,0.00005268447,0.0008323411,0.001293602],"study_design_scores_gemma":[0.0004269564,0.0003723432,0.008584251,0.001447689,0.0003854049,0.0006613241,0.001758302,0.00007507725,0.9855601,0.0002896421,0.0002608011,0.0001780606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962388,0.001156359,0.00008098844,0.001798578,0.00004786511,0.00008083422,0.000008691674,0.00001769854,0.0005701309],"genre_scores_gemma":[0.9988906,0.00004293104,0.0002097304,0.0001320419,0.0004185033,0.000003312926,0.000006274187,0.00001048761,0.0002860829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01073883,"threshold_uncertainty_score":0.4101157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007071243830052934,"score_gpt":0.2323039403032635,"score_spread":0.2252326964732106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}