{"id":"W4396675132","doi":"10.1016/s2468-1253(24)00080-3","title":"Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial","year":2024,"lang":"en","type":"article","venue":"The Lancet. Gastroenterology & hepatology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Progressive familial intrahepatic cholestasis; Cholestasis; Placebo; Medicine; Gastroenterology; Internal medicine; Bile acid; Pathology; Liver transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001262748,0.001348643,0.002803497,0.0002740136,0.0003281992,0.0007889317,0.0007173633,0.001727107,0.005141355],"category_scores_gemma":[0.001378572,0.0003749486,0.001423135,0.0003368105,0.0008231535,0.0007408931,0.0003441287,0.002094291,0.0007266963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006899813,"about_ca_system_score_gemma":0.0006955506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009033246,"about_ca_topic_score_gemma":0.001786834,"domain_scores_codex":[0.9996822,0.0001570417,0.0000177186,0.00005081355,0.00002526283,0.00006698426],"domain_scores_gemma":[0.9995313,0.0001275049,0.0001109065,0.00003181203,0.00003742494,0.0001610319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9668735,0.001501442,0.0005271124,0.001406229,0.001351477,0.0001032117,0.00004187578,0.0003090801,0.002779822,0.0002332867,0.00201005,0.02286293],"study_design_scores_gemma":[0.966038,0.02983424,0.001965228,0.00006694075,0.000511123,0.00009001655,0.00001816182,0.0002299793,0.0002155443,0.0001610763,0.0008567057,0.00001290774],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.962324,0.02801255,0.0008427573,0.002177766,0.00094841,0.00171271,0.001025671,0.0002811591,0.002675042],"genre_scores_gemma":[0.9814481,0.008289714,0.001676952,0.001775441,0.0005598421,0.001979668,0.0009752699,0.00002374239,0.00327123],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005141355,"threshold_uncertainty_score":0.01719952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291766570582021,"score_gpt":0.3252674504631796,"score_spread":0.2923497847573594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}