{"id":"W4396683941","doi":"10.4049/jimmunol.2300640","title":"S100A9: The Unusual Suspect Connecting Viral Infection and Inflammation","year":2024,"lang":"en","type":"review","venue":"The Journal of Immunology","topic":"S100 Proteins and Annexins","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"CIHR Skin Research Training Centre; Office of Extramural Research, National Institutes of Health; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"S100A9; S100A8; Inflammation; Cytokine storm; Pathogenesis; Immunology; Coronavirus disease 2019 (COVID-19); Disease; Viral infection; Cytokine; Biology; Pandemic; Virology; Medicine; Virus; Infectious disease (medical specialty); Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003292468,0.0006978954,0.0008574937,0.001862846,0.0003105978,0.0009964107,0.0006023272,0.001669297,0.002326716],"category_scores_gemma":[0.0005790148,0.0002277775,0.0003184449,0.0015171,0.0005956741,0.001654126,0.0008022067,0.002536643,0.001867974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005834005,"about_ca_system_score_gemma":0.0008962622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005581003,"about_ca_topic_score_gemma":0.0008952569,"domain_scores_codex":[0.9998895,0.00001845273,0.00001473614,0.00002368463,0.00004050457,0.00001299976],"domain_scores_gemma":[0.9998025,0.00009678031,0.00002131928,0.0000066429,0.00004811077,0.00002461393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001084015,0.00004004013,0.0003125544,0.009628632,0.00008494956,0.0008610302,0.00009468289,0.0002484519,0.004177151,0.00999299,0.06610529,0.9083459],"study_design_scores_gemma":[0.000007655777,0.00004085802,0.0004536621,0.001237411,0.00003917529,0.002773112,0.00006098386,0.00004728972,0.0004769037,0.003275846,0.9915751,0.00001204966],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001427735,0.996699,0.0002428256,0.0009231285,0.0007681745,0.000003674251,0.00001522688,0.000009268057,0.00119588],"genre_scores_gemma":[0.0009040162,0.9965931,0.0002375869,0.0004886189,0.0006117407,0.000005094038,0.0000300568,0.000002342993,0.001127405],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002326716,"threshold_uncertainty_score":0.007783651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01897563907598505,"score_gpt":0.3064236089005973,"score_spread":0.2874479698246122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}