{"id":"W4396686977","doi":"10.1016/s2666-5247(24)00024-7","title":"Assessment of CD8+ T-cell mediated immunity in an influenza A(H3N2) human challenge model in Belgium: a single centre, randomised, double-blind phase 2 study","year":2024,"lang":"en","type":"article","venue":"The Lancet Microbe","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Caprion (Canada)","funders":"Biomedical Advanced Research and Development Authority; U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response","keywords":"Double blind; CD8; Immunology; Medicine; Virology; Cytotoxic T cell; Immunity; Biology; Immune system; In vitro; Pathology; Genetics; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002175963,0.0003042572,0.0009987849,0.0004527556,0.0001135689,0.00005577305,0.000452903,0.0001077507,0.00007131692],"category_scores_gemma":[0.00007229329,0.0002144332,0.0001045351,0.0006654236,0.0001949079,0.0001845416,0.0003583651,0.001051993,0.00001611352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003351142,"about_ca_system_score_gemma":0.0002583439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007066453,"about_ca_topic_score_gemma":0.002128526,"domain_scores_codex":[0.9972188,0.0004646198,0.0007659563,0.0004158614,0.0004802034,0.0006545095],"domain_scores_gemma":[0.9984912,0.0002759315,0.0001166306,0.0008439414,0.000168462,0.0001038838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.05218575,0.02141407,0.02577183,0.001483816,0.0005938573,0.0004296726,0.04753394,0.001622218,0.846888,0.0003550064,0.0008786205,0.0008432297],"study_design_scores_gemma":[0.9214746,0.004007942,0.01379601,0.001547751,0.0004539527,0.000009109678,0.009849134,0.02376787,0.02148632,0.0004397639,0.002292933,0.0008745751],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988867,0.003323628,0.000009845905,0.0005445478,0.00005391525,0.003046139,0.00006379699,0.00007996793,0.004011091],"genre_scores_gemma":[0.998807,0.000264691,0.0001267594,0.0002846723,0.0001174161,0.0001594462,0.00004716805,0.00004717594,0.0001456852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8692889,"threshold_uncertainty_score":0.8744333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2238977608478224,"score_gpt":0.4623837895722429,"score_spread":0.2384860287244205,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}