{"id":"W4396688693","doi":"10.1002/advs.202401617","title":"Advancements in Aptamer‐Driven DNA Nanostructures for Precision Drug Delivery","year":2024,"lang":"en","type":"article","venue":"Advanced Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Ministry of Science and ICT, South Korea; National Research Foundation of Korea; National Research Foundation","keywords":"Aptamer; Nanotechnology; Drug delivery; DNA origami; DNA nanotechnology; Targeted drug delivery; Nanocarriers; Nanomedicine; Oligonucleotide; DNA; Nanostructure; Nanomaterials; Chemistry; Materials science; Nanoparticle; Biology; Molecular biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008762981,0.0006260629,0.0005146337,0.0008744298,0.0001635425,0.0005723417,0.0004140628,0.000620705,0.001164914],"category_scores_gemma":[0.0005362332,0.0003961458,0.0005098216,0.0008395422,0.0003247051,0.001086148,0.0005194049,0.001240673,0.0007502846],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005918364,"about_ca_system_score_gemma":0.0005810016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004172094,"about_ca_topic_score_gemma":0.0005213544,"domain_scores_codex":[0.9996486,0.00004516566,0.00003919722,0.00009000358,0.0001446579,0.00003242991],"domain_scores_gemma":[0.9997249,0.0001002129,0.0000500245,0.00001901875,0.00008759085,0.0000182094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001315307,0.0001715961,0.0003846983,0.006542464,0.00008434871,0.0003141646,0.0002790193,0.002514126,0.5324228,0.01718568,0.002848311,0.4371212],"study_design_scores_gemma":[0.00003495956,0.0009935729,0.001125302,0.0005270725,0.0001456686,0.001315791,0.00007737816,0.004531699,0.4773722,0.003362146,0.5104265,0.00008765345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.02625924,0.9054962,0.05194017,0.001284405,0.0006127725,0.0001340695,0.0001485881,0.0002225268,0.01390211],"genre_scores_gemma":[0.1057358,0.8407269,0.04401616,0.001015946,0.0005312692,0.0001643179,0.000276511,0.00004952611,0.00748351],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001164914,"threshold_uncertainty_score":0.004634321,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006746515337562571,"score_gpt":0.2998695095252099,"score_spread":0.2931229941876473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}