{"id":"W4396688833","doi":"10.7554/elife.97043","title":"Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila","year":2024,"lang":"en","type":"article","venue":"eLife","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Institute of Mental Health; Japan Society for the Promotion of Science; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Julius-Maximilians-Universität Würzburg; Vetenskapsrådet; Deutsche Forschungsgemeinschaft","keywords":"Homeostasis; Hormone; Guanylate cyclase; Diuretic; Receptor; NPR1; GUCY1A3; Guanylate cyclase 2C; Endocrinology; Pharmacology; Internal medicine; Biology; Medicine; Heart failure; Natriuretic peptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006254751,0.0003126853,0.0001357958,0.0001759079,0.0001635455,0.0001698062,0.0001450739,0.0001686452,0.0006868928],"category_scores_gemma":[0.00005045474,0.0001090176,0.0002009507,0.00007900436,0.0001742033,0.0001800251,0.0001697474,0.0003499495,0.000245593],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412353,"about_ca_system_score_gemma":0.0001508416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001671953,"about_ca_topic_score_gemma":0.004053808,"domain_scores_codex":[0.9999411,0.000007469834,0.00000546985,0.00001882282,0.0000161951,0.00001085831],"domain_scores_gemma":[0.9999655,0.000003588463,0.00001106417,0.00000359027,0.000004652877,0.00001155769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001422477,0.000001593603,0.0001947299,0.00001862173,0.000001449155,0.00003698211,0.000005248706,0.0000377932,0.9990839,0.00007925646,0.00002461548,0.000501636],"study_design_scores_gemma":[0.000024247,0.000112988,0.02387028,0.00001356417,0.00002770914,0.0003453196,0.00005954772,0.002939319,0.9663339,0.0000988763,0.006162989,0.00001120303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893966,0.002463107,0.004144183,0.0001484865,0.00003484029,0.00003973111,0.001096445,0.0001200575,0.00255661],"genre_scores_gemma":[0.9883522,0.001470795,0.005764795,0.0001431607,0.000008882147,0.00003625204,0.0008595591,0.00002942411,0.00333489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001671953,"threshold_uncertainty_score":0.003324449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02866874687458033,"score_gpt":0.3001767430063261,"score_spread":0.2715079961317458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}