{"id":"W4396693780","doi":"10.3390/genes15050592","title":"The Association between Mutational Signatures and Clinical Outcomes among Patients with Early-Onset Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Foothills Medical Centre; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Oncology; Internal medicine; Cancer; Medicine; Association (psychology); Genetics; Biology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000180665,0.00009128804,0.00007945904,0.0000149281,0.0001318086,0.0000898417,0.00008107932,0.0001171588,0.000008523996],"category_scores_gemma":[0.00003796222,0.00005806522,0.00004764378,0.00006306319,0.00009106084,0.000006210337,0.00004363127,0.00008909443,0.000003398489],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000473494,"about_ca_system_score_gemma":0.0001269175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005318659,"about_ca_topic_score_gemma":0.0003329707,"domain_scores_codex":[0.9992625,0.00005734952,0.0001505424,0.0002294294,0.0001700948,0.0001300435],"domain_scores_gemma":[0.9995355,0.00013402,0.00005919659,0.0001126934,0.000121595,0.00003700674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001575054,0.000007333019,0.981162,0.00000429166,0.0003716442,3.772139e-7,0.00002346191,0.00003209303,0.0000235846,0.000006837639,0.001996228,0.01635644],"study_design_scores_gemma":[0.000222907,0.00004186192,0.9933829,0.00000849092,0.00007520031,5.369512e-7,0.00001300234,0.00001472596,0.0002262453,0.0000559322,0.005867958,0.0000902456],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968089,0.001687001,0.00005596638,0.0005698389,0.0003507108,0.0001247873,0.0003513913,0.00001347595,0.00003788656],"genre_scores_gemma":[0.998404,0.000283902,0.0001018185,0.00009298923,0.0003485114,0.00004059324,0.0001377225,0.00001636717,0.0005740934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0162662,"threshold_uncertainty_score":0.2367831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007786264974710767,"score_gpt":0.2930648284411207,"score_spread":0.28527856346641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}