{"id":"W4396693780","doi":"10.3390/genes15050592","title":"The Association between Mutational Signatures and Clinical Outcomes among Patients with Early-Onset Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Health Services; Foothills Medical Centre; University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Breast cancer; Oncology; Internal medicine; Cancer; Medicine; Association (psychology); Genetics; Biology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002734585,0.0001646016,0.0002298937,0.0007235977,0.0003219963,0.0004390765,0.0002507453,0.0001880569,0.0008510558],"category_scores_gemma":[0.00123166,0.0001030249,0.0001391755,0.000862692,0.0002341733,0.00009664767,0.000300717,0.000245311,0.0001237107],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008107236,"about_ca_system_score_gemma":0.0008753813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1369642,"about_ca_topic_score_gemma":0.3090598,"domain_scores_codex":[0.9998373,0.00002159406,0.00001064142,0.0000389443,0.00004981493,0.00004168295],"domain_scores_gemma":[0.9995759,0.0001010467,0.0001033513,0.00003722936,0.0001046183,0.00007792213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001508921,0.000008917159,0.9948215,0.00000804884,0.00003494553,0.00007659839,0.00005798941,0.0001628597,0.001635649,0.00001287931,0.00008399651,0.002945697],"study_design_scores_gemma":[0.000001782787,0.000009685873,0.9994859,0.00000128305,0.00001155027,0.0001015421,0.00004645022,0.0001444275,0.0001048017,0.00001107146,0.00008044583,0.000001177125],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993454,0.0001320591,0.00005446014,0.00001257463,8.126222e-7,0.000002218345,0.0002803973,0.000002997848,0.0001690494],"genre_scores_gemma":[0.9991786,0.00006918909,0.00006582083,0.000005170415,0.000001063998,0.000001568097,0.0005198154,0.000001778524,0.000157013],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1369642,"threshold_uncertainty_score":0.272334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007786264974710767,"score_gpt":0.2930648284411207,"score_spread":0.28527856346641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}