{"id":"W4396695661","doi":"10.1002/cpz1.1012","title":"Establishment of Transgene‐Free Porcine Induced Pluripotent Stem Cells","year":2024,"lang":"en","type":"article","venue":"Current Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Alberta Children's Hospital Research Institute; Natural Sciences and Engineering Research Council of Canada; Faculty of Veterinary Medicine, University of Calgary; Canada Research Chairs","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; SOX2; Transgene; KLF4; Homeobox protein NANOG; Cell biology; Somatic cell; Molecular biology; Embryonic stem cell; Computational biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009871583,0.0004889567,0.0006481798,0.001027346,0.000581337,0.0007230217,0.0009320653,0.0007103254,0.007902834],"category_scores_gemma":[0.0006075314,0.0005496035,0.0006329893,0.000817197,0.0003642307,0.0004788938,0.0008443354,0.001464665,0.008561965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003077818,"about_ca_system_score_gemma":0.0007810605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005380389,"about_ca_topic_score_gemma":0.0009191131,"domain_scores_codex":[0.9990397,0.00008926206,0.0001461135,0.0002130884,0.0003928527,0.0001189209],"domain_scores_gemma":[0.9996208,0.00005799689,0.00003823262,0.00007291903,0.0001441263,0.00006600256],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231124,0.00008135253,0.0004580117,0.0006201249,0.00001787559,0.0008841555,0.0002062946,0.000447631,0.9703532,0.003407304,0.003226462,0.02017447],"study_design_scores_gemma":[0.00008927745,0.000940755,0.004946661,0.0002914928,0.00009286679,0.003005708,0.0001699214,0.003372265,0.6693209,0.001243864,0.3164316,0.00009478824],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.2845108,0.01265555,0.4704753,0.000972211,0.00210386,0.01381238,0.05733131,0.006055173,0.1520834],"genre_scores_gemma":[0.3875636,0.0130385,0.3605708,0.001461196,0.0002731018,0.01108529,0.131375,0.001416208,0.09321624],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.007902834,"threshold_uncertainty_score":0.02643758,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05295101710787135,"score_gpt":0.3455012925100752,"score_spread":0.2925502754022039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}