{"id":"W4396695661","doi":"10.1002/cpz1.1012","title":"Establishment of Transgene‐Free Porcine Induced Pluripotent Stem Cells","year":2024,"lang":"en","type":"article","venue":"Current Protocols","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Alberta Children's Hospital Research Institute; Natural Sciences and Engineering Research Council of Canada; Faculty of Veterinary Medicine, University of Calgary; Canada Research Chairs","keywords":"Reprogramming; Biology; Induced pluripotent stem cell; SOX2; Transgene; KLF4; Homeobox protein NANOG; Cell biology; Somatic cell; Molecular biology; Embryonic stem cell; Computational biology; Genetics; Cell; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004096443,0.0002622143,0.0002668007,0.0001442668,0.00004624498,0.00008120482,0.0006631743,0.0001469498,0.00007307526],"category_scores_gemma":[0.00001651762,0.0002274052,0.0002105925,0.0002724884,0.00007219078,0.0000119162,0.0002972677,0.0002445825,0.00004312796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004707589,"about_ca_system_score_gemma":0.0002902334,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007203291,"about_ca_topic_score_gemma":0.000004806571,"domain_scores_codex":[0.9977814,0.0001159815,0.0004960241,0.0006281074,0.0005348091,0.0004436568],"domain_scores_gemma":[0.9987195,0.0000170797,0.00008263764,0.0008546819,0.0001466947,0.0001794436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001206246,0.0002529272,0.0001828324,0.001333244,0.00006673755,0.00001064474,0.00005107999,0.00003555728,0.9525182,0.000112975,0.006743961,0.03857128],"study_design_scores_gemma":[0.0007252191,0.0005232026,0.00007802842,0.0004002844,0.00001542371,0.000005557748,0.00002282424,0.0001344894,0.7952297,0.00004895521,0.202617,0.0001993458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8153994,0.007857108,0.00636691,0.0007337614,0.001681357,0.1648236,0.0005630717,0.0001910885,0.002383712],"genre_scores_gemma":[0.9317164,0.000272207,0.0002637599,0.00002942403,0.0005387591,0.06527479,0.0001210323,0.00009607794,0.0016875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.195873,"threshold_uncertainty_score":0.9273313,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05295101710787135,"score_gpt":0.3455012925100752,"score_spread":0.2925502754022039,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}