{"id":"W4396695882","doi":"10.1038/s44161-024-00471-7","title":"Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways","year":2024,"lang":"en","type":"article","venue":"Nature Cardiovascular Research","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; York University; Stem Cell Network; University Health Network; Toronto General Hospital; University of Toronto; Ted Rogers Centre for Heart Research","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Hospital for Sick Children; Government of Canada; National Institutes of Health; Stem Cell Network","keywords":"Cell biology; Biology; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001455429,0.0001929539,0.0005510813,0.0004502837,0.0001569177,0.00003809452,0.00006343951,0.0002519879,0.00002184596],"category_scores_gemma":[0.0001656357,0.0001467633,0.0002626507,0.0006668332,0.0002090062,0.00006328978,0.00008615034,0.001274945,0.00001249616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002784911,"about_ca_system_score_gemma":0.0001541643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002633137,"about_ca_topic_score_gemma":5.543517e-7,"domain_scores_codex":[0.9975823,0.0002444124,0.0002320767,0.0004620052,0.001158832,0.0003203989],"domain_scores_gemma":[0.9989495,0.0001410096,0.00001815024,0.0003225601,0.0004556389,0.0001131762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000582992,0.00002923873,0.0002174017,0.002034112,0.002131678,0.0002356239,0.0007456074,0.00002691125,0.9655894,0.001891765,0.0006470864,0.0263929],"study_design_scores_gemma":[0.0009880663,0.000469307,0.06055277,0.001653543,0.0003963946,0.0002329387,0.0003045987,0.0001599584,0.9000938,0.00009000337,0.03478711,0.0002715012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.629199,0.3598816,0.009117485,0.0003070219,0.0005826913,0.0006831662,0.000006858659,0.0000602486,0.0001619329],"genre_scores_gemma":[0.9951019,0.001472597,0.001278479,0.000009766064,0.0008310811,0.00007668765,0.0000985098,0.00003910288,0.001091868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.365903,"threshold_uncertainty_score":0.5984836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04243627004861173,"score_gpt":0.3407984568606575,"score_spread":0.2983621868120457,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}