{"id":"W4396697101","doi":"10.1002/anie.202407862","title":"Inside Cover: A Sensitive Technique Unravels the Kinetics of Activation and <i>Trans</i> ‐Cleavage of CRISPR‐Cas Systems (Angew. Chem. Int. Ed. 22/2024)","year":2024,"lang":"en","type":"paratext","venue":"Angewandte Chemie International Edition","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Kinetics; Chemistry; Ribonucleoprotein; Nucleic acid; CRISPR; Cleavage (geology); Reaction rate constant; Dissociation constant; INT; RNA; Stereochemistry; Biophysics; Biochemistry; Materials science; Biology; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001667016,0.0002908706,0.0002999668,0.0001249866,0.00002499465,0.00004061999,0.000195295,0.0004343911,0.00006838673],"category_scores_gemma":[0.0000785204,0.000257294,0.0001365638,0.0001129349,0.0001425548,0.00001125737,0.0001318345,0.0003030587,0.00001322134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006075187,"about_ca_system_score_gemma":0.00006106561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000778912,"about_ca_topic_score_gemma":0.000003296965,"domain_scores_codex":[0.9986523,0.00002882492,0.0004499553,0.0003829291,0.0003319727,0.0001540221],"domain_scores_gemma":[0.9990031,0.00006428978,0.0002684534,0.0002585445,0.0003604141,0.00004524232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004856116,0.0000327223,0.000002322948,0.0003981689,0.0001995918,0.000001872332,0.0001246584,0.0001990961,0.7408223,0.00001967594,0.2580486,0.0001023874],"study_design_scores_gemma":[0.000232381,0.000107568,0.0000267494,0.0005998737,0.00008646075,0.00004295942,0.0001740578,0.00004114708,0.8755777,0.00002869374,0.1228763,0.0002061601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.001553112,0.005170696,0.9455503,0.0004728909,0.004337369,0.0008600259,0.002639146,0.00002152264,0.0393949],"genre_scores_gemma":[0.9825522,0.005408959,0.000162628,0.0001085956,0.002029966,0.0001069864,0.003119425,0.00005847125,0.006452711],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9809992,"threshold_uncertainty_score":0.9999879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007496362484837817,"score_gpt":0.2824248628758148,"score_spread":0.274928500390977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}