{"id":"W4396697101","doi":"10.1002/anie.202407862","title":"Inside Cover: A Sensitive Technique Unravels the Kinetics of Activation and <i>Trans</i> ‐Cleavage of CRISPR‐Cas Systems (Angew. Chem. Int. Ed. 22/2024)","year":2024,"lang":"en","type":"paratext","venue":"Angewandte Chemie International Edition","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Kinetics; Chemistry; Ribonucleoprotein; Nucleic acid; CRISPR; Cleavage (geology); Reaction rate constant; Dissociation constant; INT; RNA; Stereochemistry; Biophysics; Biochemistry; Materials science; Biology; Physics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005987464,0.000881248,0.000604249,0.001019314,0.0008671523,0.001557531,0.00108134,0.001521243,0.03153658],"category_scores_gemma":[0.0007125271,0.0007648231,0.0006258863,0.0006704447,0.0009135781,0.002086132,0.001398893,0.002964441,0.02205139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008106337,"about_ca_system_score_gemma":0.0004261506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004971976,"about_ca_topic_score_gemma":0.0008007545,"domain_scores_codex":[0.9993768,0.00004611436,0.00001572428,0.0001462194,0.0003434691,0.00007164859],"domain_scores_gemma":[0.9996356,0.0001257779,0.0000473307,0.0000696992,0.00006899106,0.00005268492],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001720787,0.00006782865,0.0001540432,0.0004025295,0.00002355861,0.0003333805,0.0001517107,0.0003454217,0.7094581,0.01249541,0.1526587,0.1237372],"study_design_scores_gemma":[0.00001865949,0.0001337947,0.0005974122,0.00005478789,0.00002446651,0.0007701407,0.00005845248,0.002492465,0.4909507,0.002754521,0.5020931,0.00005148967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"other","genre_scores_codex":[0.0557779,0.0505186,0.4568714,0.02293372,0.03709863,0.0004575335,0.00717788,0.02723531,0.3419291],"genre_scores_gemma":[0.175814,0.02233008,0.1572252,0.01152663,0.004123992,0.0007931336,0.004587043,0.004856406,0.6187435],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.03153658,"threshold_uncertainty_score":0.1055003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007496362484837817,"score_gpt":0.2824248628758148,"score_spread":0.274928500390977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}