{"id":"W4396705273","doi":"10.1002/ajh.27312","title":"Clinically meaningful improvements in patient‐reported outcomes in mitapivat‐treated patients with pyruvate kinase deficiency","year":2024,"lang":"en","type":"letter","venue":"American Journal of Hematology","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Agios Pharmaceuticals","keywords":"Medicine; Pyruvate kinase; Clinical trial; Pyruvate kinase deficiency; Disease; Intensive care medicine; Internal medicine; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008805224,0.000274224,0.0007755776,0.0001590031,0.0004929691,0.0005837298,0.0003485965,0.003614204,0.001870672],"category_scores_gemma":[0.003357433,0.0001084763,0.0003016718,0.0002814796,0.0003828988,0.0003205399,0.0001356432,0.00214715,0.0008437257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007569174,"about_ca_system_score_gemma":0.0005832423,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009955671,"about_ca_topic_score_gemma":0.002519651,"domain_scores_codex":[0.9995609,0.0001987689,0.00005607316,0.00003063964,0.0000956824,0.00005787348],"domain_scores_gemma":[0.9986432,0.00076442,0.0001220437,0.00003909944,0.0002215267,0.0002097189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.007822918,0.001131717,0.07828446,0.0004754184,0.000331144,0.05244093,0.0003113436,0.001540091,0.009736749,0.003330111,0.6033383,0.2412567],"study_design_scores_gemma":[0.01313521,0.01044341,0.2164875,0.0009557436,0.0008036457,0.1167026,0.0007151707,0.0132347,0.01016432,0.01519893,0.6019445,0.0002144279],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.1792633,0.01860222,0.001984495,0.7385245,0.01014194,0.0002136938,0.001171511,0.0002921621,0.04980613],"genre_scores_gemma":[0.6210245,0.008947209,0.001862588,0.3269746,0.02115753,0.0002067219,0.0009700255,0.00004220689,0.01881465],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003614204,"threshold_uncertainty_score":0.006258011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311945309357682,"score_gpt":0.2755375611461521,"score_spread":0.2624181080525753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}