{"id":"W4396707161","doi":"10.1038/s41531-024-00704-3","title":"Genetic variation and pesticide exposure influence blood DNA methylation signatures in females with early-stage Parkinson’s disease","year":2024,"lang":"en","type":"article","venue":"npj Parkinson s Disease","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Michael Smith Health Research BC; BC Children's Hospital; University of British Columbia","funders":"Sorbonne Université; Agence Nationale de Sécurité du Médicament et des Produits de Santé; Canadian HIV Trials Network, Canadian Institutes of Health Research; Bundesministerium für Bildung und Forschung; Dartmouth College; Agence Nationale de la Recherche; Government of Canada; Canadian Institutes of Health Research; EU Joint Programme – Neurodegenerative Disease Research","keywords":"Parkinson's disease; Disease; DNA methylation; Stage (stratigraphy); Biology; Genetic variation; Genetics; Medicine; Physiology; Bioinformatics; Gene; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189703,0.0001961509,0.0002284461,0.0003276443,0.0002003889,0.0002388599,0.0001278985,0.0001784841,0.001635798],"category_scores_gemma":[0.0009624116,0.0001279873,0.0002626474,0.0002841333,0.0001367846,0.0001068122,0.0001563056,0.000166932,0.0001506947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008642495,"about_ca_system_score_gemma":0.00008456159,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002360895,"about_ca_topic_score_gemma":0.002841042,"domain_scores_codex":[0.9997916,0.00007498653,0.0000111145,0.00007904446,0.00002330755,0.00001994977],"domain_scores_gemma":[0.9996002,0.0001204083,0.0001564921,0.00005172057,0.0000410543,0.00003012898],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004136857,0.0000194464,0.9792158,0.000009737431,0.0001177151,0.0001245477,0.000116893,0.00007546009,0.01524946,0.00003286092,0.00007332084,0.004551162],"study_design_scores_gemma":[0.000003358261,0.00006925757,0.9984378,0.000002030124,0.00003647825,0.0001760114,0.0000621188,0.0001703295,0.0008544179,0.00004715512,0.0001394802,0.000001551659],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991038,0.0001392311,0.0003445898,0.00002250715,0.00000223121,0.000002011391,0.0001754609,0.000003860278,0.0002062824],"genre_scores_gemma":[0.9995573,0.00003442692,0.0001435888,0.000008284205,0.000002087896,0.000001987271,0.00007121107,0.000002892102,0.0001781253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002360895,"threshold_uncertainty_score":0.005472243,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01307598261529023,"score_gpt":0.2572895637827116,"score_spread":0.2442135811674213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}