{"id":"W4396725426","doi":"10.1101/2024.05.06.592703","title":"Jchain-Diphtheria Toxin Receptor Mice Allow for Diphtheria Toxin-Mediated Depletion of Antibody-Secreting Cells and Analysis of Differentiation Kinetics","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Toxin Mechanisms and Immunotoxins","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation","keywords":"Diphtheria toxin; Diphtheria; Antibody; Kinetics; Toxin; Immunology; Chemistry; Biology; Microbiology; Physics; Vaccination","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00080005,0.0006227486,0.001333989,0.0007274305,0.0001105225,0.00007338552,0.0004499245,0.001156747,0.0002430999],"category_scores_gemma":[0.0002950867,0.0006344502,0.0004491154,0.0007615977,0.0002072068,0.00006090981,0.0005119507,0.0005931304,0.00002056322],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001232704,"about_ca_system_score_gemma":0.0001659712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001015056,"about_ca_topic_score_gemma":0.000009617009,"domain_scores_codex":[0.9968609,0.0003203669,0.001167041,0.0009870479,0.0001345766,0.0005300577],"domain_scores_gemma":[0.9971502,0.0003031075,0.001129787,0.0008366421,0.0005125177,0.00006776762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002060423,0.0002338662,0.001087054,0.0008902018,0.003207114,0.000001333017,0.0000929879,0.00003900913,0.9937497,0.0004174388,0.0000676064,0.000007632415],"study_design_scores_gemma":[0.0008410504,0.0002710511,0.02229965,0.0005060686,0.002000657,1.669057e-8,0.00002378009,0.0008217813,0.9718022,0.00001020897,0.0008417722,0.000581732],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815465,0.004103479,0.007086366,0.00005735412,0.002221164,0.001081336,0.003747395,0.0001535365,0.000002869832],"genre_scores_gemma":[0.9939798,0.0007504208,0.004788942,0.00003465717,0.00008665871,0.0001231873,0.00007609103,0.0001346018,0.00002562751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02194748,"threshold_uncertainty_score":0.9996107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008942459622508532,"score_gpt":0.2208110442636296,"score_spread":0.2118685846411211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}