{"id":"W4396729214","doi":"10.1002/acn3.52025","title":"Polygenic liability for anxiety in association with comorbid anxiety in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Manitoba Health; Nova Scotia Health Authority; Dalhousie University; University of Manitoba","funders":"Janssen Canada; National Institute of Mental Health; Uppsala Multidisciplinary Center for Advanced Computational Science; Takeda Canada; Pfizer Canada; Amgen Canada; EMD Serono; Genentech; AbbVie Canada; Sandoz Canada; Mitsubishi Tanabe Pharma Corporation; Crohn's and Colitis Canada; Vetenskapsrådet; National Heart, Lung, and Blood Institute; Multiple Sclerosis Society; Canadian Institutes of Health Research; Prothena; AveXis; Amgen; Horizon Pharmaceuticals; Sanofi; GW Pharmaceuticals; Eli Lilly and Company; U.S. Department of Defense; Genome Canada; University of Alabama; National Institutes of Health; Mylan; Regeneron Pharmaceuticals; Eli Lilly Canada; Cleveland Clinic Foundation; Alliance de recherche numérique du Canada; Bristol-Myers Squibb; Cleveland Clinic; University of Pennsylvania; U.S. Department of Veterans Affairs; Office of Research and Development; Alexion Pharmaceuticals; University of Texas Health Science Center at Houston; National Center for Advancing Translational Sciences; Teva Pharmaceutical Industries; University of Manitoba; Research Nova Scotia; Celgene; Pfizer; Biogen; CSL Behring","keywords":"Medicine; Anxiety; Association (psychology); Multiple sclerosis; Comorbidity; Psychiatry; Liability; MEDLINE; Clinical psychology; Psychotherapist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001920662,0.0004731911,0.0004766537,0.001082248,0.0004771549,0.0008288943,0.0003571735,0.000530977,0.002267506],"category_scores_gemma":[0.006062355,0.0002620094,0.001338622,0.00144206,0.0006321839,0.0002992484,0.0008443833,0.0005610329,0.00008014905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067109,"about_ca_system_score_gemma":0.0004352937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01352743,"about_ca_topic_score_gemma":0.01238389,"domain_scores_codex":[0.9984807,0.0006113536,0.000120017,0.0004553301,0.0001832914,0.000149277],"domain_scores_gemma":[0.996802,0.001220793,0.00135143,0.0003115156,0.0001445251,0.0001698311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005065888,0.00002776255,0.9872171,0.00009399279,0.002036993,0.0003105079,0.0001122042,0.0006550557,0.001927034,0.0002386821,0.0001977865,0.006676278],"study_design_scores_gemma":[0.00001652737,0.00006470845,0.9976661,0.00002986033,0.0005459954,0.0004307764,0.00003122336,0.0007219663,0.00009176723,0.0003119448,0.00008195564,0.000007148853],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953934,0.002104361,0.001074694,0.0002684575,0.0000150663,0.00001691586,0.0005654591,0.00003374577,0.0005278856],"genre_scores_gemma":[0.9990386,0.0002767798,0.0003382076,0.00003035844,0.0000184953,0.000008382374,0.0002236213,0.000002720793,0.00006300965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01352743,"threshold_uncertainty_score":0.02689737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2403196150832919,"score_gpt":0.4236006809717343,"score_spread":0.1832810658884424,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}