{"id":"W4396732203","doi":"10.1016/j.annonc.2024.04.013","title":"Abemaciclib plus a nonsteroidal aromatase inhibitor as initial therapy for HR+, HER2− advanced breast cancer: final overall survival results of MONARCH 3","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":206,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Durham","funders":"Sanofi Genzyme; Gilead Sciences; Sanofi; Pfizer; AstraZeneca; Daiichi Sankyo Europe; Eli Lilly and Company","keywords":"Medicine; Nonsteroidal; Aromatase inhibitor; Aromatase; Oncology; Internal medicine; Breast cancer; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004576333,0.0003061931,0.000974673,0.0002367458,0.00005128216,0.000009920001,0.0002007575,0.0002250228,0.0001512007],"category_scores_gemma":[0.00009462432,0.0002667698,0.0002971616,0.000263714,0.000397978,0.0002099337,0.00006935806,0.0002962928,0.00001481158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001327918,"about_ca_system_score_gemma":0.001538257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004082735,"about_ca_topic_score_gemma":0.0001013358,"domain_scores_codex":[0.9976171,0.0001141818,0.0008272671,0.0005368493,0.0003815709,0.0005230667],"domain_scores_gemma":[0.9980429,0.0005983115,0.0003036507,0.0003837305,0.0004929525,0.0001785025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.129747,0.0009944886,0.0004032942,0.0007694232,0.0007908566,0.0003053223,0.001821514,0.000253758,0.05634258,0.0007592387,0.003389776,0.8044228],"study_design_scores_gemma":[0.08314753,0.04076596,0.01728279,0.003075813,0.0003199512,0.001933855,0.001236614,0.001140657,0.2543641,0.008231947,0.5872734,0.001227382],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699497,0.006044035,0.0001542605,0.01660919,0.001012695,0.001108974,0.003995148,0.00009666292,0.001029295],"genre_scores_gemma":[0.9940402,0.001569897,0.001185322,0.001266143,0.0009260236,0.0002654065,0.0002316016,0.00006865562,0.000446755],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8031954,"threshold_uncertainty_score":0.9999784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035576446243398,"score_gpt":0.4507032766043178,"score_spread":0.3471456319799779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}