{"id":"W4396736380","doi":"10.1186/s13048-024-01404-5","title":"EGF-like growth factors upregulate pentraxin 3 expression in human granulosa-lutein cells","year":2024,"lang":"en","type":"article","venue":"Journal of Ovarian Research","topic":"Biomarkers in Disease Mechanisms","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Division of Materials Research; China Medical University; China Scholarship Council; Canadian Institutes of Health Research; China Medical University Hospital; National Natural Science Foundation of China","keywords":"Amphiregulin; Epiregulin; Downregulation and upregulation; Epidermal growth factor; PTX3; Gene knockdown; Cell biology; Epidermal growth factor receptor; Signal transduction; Chemistry; TGF alpha; Cancer research; Endocrinology; Internal medicine; Biology; Receptor; Cell culture; Medicine; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009546206,0.0001395873,0.0002061221,0.0001972578,0.000131144,0.0002093499,0.00004850964,0.0001561495,0.001108855],"category_scores_gemma":[0.0001104378,0.00007758271,0.0002167362,0.0001653148,0.0001327582,0.00008672893,0.0001685851,0.0002677873,0.000385664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001743369,"about_ca_system_score_gemma":0.0001708547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009163652,"about_ca_topic_score_gemma":0.0009830067,"domain_scores_codex":[0.9999325,0.00001261746,0.000006351566,0.000009870747,0.00001775936,0.0000208631],"domain_scores_gemma":[0.9999521,0.0000142337,0.000007779286,0.000008955244,0.000006753825,0.00001016916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002885172,0.00003703738,0.001182405,0.00005690078,0.000006177213,0.0002436307,0.00008527274,0.0000325463,0.9952448,0.00003656108,0.0001102318,0.002675838],"study_design_scores_gemma":[0.0001059379,0.0009181288,0.06329743,0.0000194293,0.00004951084,0.001226387,0.0002202209,0.0008582743,0.9220042,0.00008330668,0.01120653,0.00001072793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949366,0.002643893,0.0006493089,0.0001035571,0.00002129909,0.00005144516,0.0003106804,0.00004281903,0.001240421],"genre_scores_gemma":[0.9955801,0.0009649933,0.0009644261,0.0001347374,0.00001354103,0.00004947503,0.0005630084,0.000008340699,0.001721358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001108855,"threshold_uncertainty_score":0.003709495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04168183430440753,"score_gpt":0.3386187712945979,"score_spread":0.2969369369901904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}