{"id":"W4396744109","doi":"10.1016/j.labinv.2024.102076","title":"Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Queen's University; Research Institute in Oncology and Hematology; Manitoba Health; Mount Sinai Hospital; University of British Columbia; St. Michael's Hospital; North York General Hospital; CancerCare Manitoba; University of Manitoba; Trillium Health Centre; Health Sciences Centre; University of Alberta; University Health Network; Ottawa Hospital; Sunnybrook Health Science Centre; McMaster University; University of Saskatchewan; Children's Hospital Research Institute of Manitoba; Western University; Nova Scotia Health Authority; Saskatchewan Health Authority; Saskatchewan Health; Saskatoon City Hospital; Dalhousie University; Royal University Hospital; University of Toronto","funders":"Eli Lilly and Company","keywords":"Immunohistochemistry; Breast cancer; Pathology; Medicine; Cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01787113,0.001603302,0.001256407,0.004075631,0.001683805,0.001960695,0.002640393,0.001701919,0.02520956],"category_scores_gemma":[0.01794794,0.001272502,0.001321341,0.002407977,0.001366951,0.001423598,0.002039077,0.001491649,0.01048506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002068599,"about_ca_system_score_gemma":0.003332167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01009212,"about_ca_topic_score_gemma":0.04777312,"domain_scores_codex":[0.9819986,0.005473683,0.001213008,0.002646812,0.007591249,0.001076664],"domain_scores_gemma":[0.9846436,0.003022311,0.001408901,0.003716121,0.006100249,0.001108828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.005211209,0.001208886,0.1738364,0.003771416,0.0007661827,0.001117732,0.002286932,0.001769029,0.4184036,0.008912084,0.09232283,0.2903937],"study_design_scores_gemma":[0.0006072253,0.003427633,0.3564426,0.001017122,0.0007930874,0.01070715,0.001401676,0.01376548,0.2898225,0.006638555,0.3148838,0.0004931925],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2885697,0.02530501,0.5049322,0.003946707,0.0026787,0.01347296,0.01304042,0.02383782,0.1242165],"genre_scores_gemma":[0.4633921,0.004743295,0.4561589,0.002563587,0.0002607611,0.006710683,0.01043492,0.002912444,0.05282319],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02520956,"threshold_uncertainty_score":0.0945127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715007953473023,"score_gpt":0.3289699856507157,"score_spread":0.3018199061159854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}