{"id":"W4396744109","doi":"10.1016/j.labinv.2024.102076","title":"Fit-for-Purpose Ki-67 Immunohistochemistry Assays for Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Queen's University; Research Institute in Oncology and Hematology; Manitoba Health; Mount Sinai Hospital; University of British Columbia; St. Michael's Hospital; North York General Hospital; CancerCare Manitoba; University of Manitoba; Trillium Health Centre; Health Sciences Centre; University of Alberta; University Health Network; Ottawa Hospital; Sunnybrook Health Science Centre; McMaster University; University of Saskatchewan; Children's Hospital Research Institute of Manitoba; Western University; Nova Scotia Health Authority; Saskatchewan Health Authority; Saskatchewan Health; Saskatoon City Hospital; Dalhousie University; Royal University Hospital; University of Toronto","funders":"Eli Lilly and Company","keywords":"Immunohistochemistry; Breast cancer; Pathology; Medicine; Cancer; Oncology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002294138,0.0001535797,0.0001989338,0.00006379967,0.00008640352,0.00005334825,0.00005718059,0.0001152572,0.0001844565],"category_scores_gemma":[0.00006798872,0.000144616,0.0001027159,0.0003111725,0.0000938805,0.0001351769,0.00001114435,0.0001281039,0.00001414606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002927309,"about_ca_system_score_gemma":0.0009242622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005170802,"about_ca_topic_score_gemma":0.00001030157,"domain_scores_codex":[0.9990793,0.00001364727,0.0002320824,0.0003112536,0.0001600503,0.0002036977],"domain_scores_gemma":[0.9991481,0.00006128517,0.00006030965,0.0002285458,0.0003409972,0.0001607693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001483843,0.00002606337,0.0008187097,0.002033466,0.0001336085,0.000005666827,0.0003424583,0.00001993051,0.9069548,0.001439174,0.06915526,0.0189225],"study_design_scores_gemma":[0.001801303,0.0001434092,0.003137511,0.001014676,0.0007286681,0.00002757783,0.0001682142,0.001421154,0.5272582,0.001381626,0.4624963,0.0004213783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9369677,0.02690282,0.003582635,0.01426939,0.003603242,0.002862757,0.01010688,0.0006256715,0.001078862],"genre_scores_gemma":[0.9769351,0.0004393377,0.007577905,0.003940118,0.002778522,0.002161396,0.0007676463,0.0001430402,0.005256905],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3933411,"threshold_uncertainty_score":0.5897271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02715007953473023,"score_gpt":0.3289699856507157,"score_spread":0.3018199061159854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}