{"id":"W4396746795","doi":"10.3390/molecules29102200","title":"Novel Combretastatin A-4 Analogs—Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Tubulin; Combretastatin; Chemistry; Sulforhodamine B; Microtubule; Stereochemistry; Colchicine; In vitro; In vivo; Cytotoxicity; Biochemistry; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002092466,0.0002176792,0.0002980049,0.00003920377,0.0001123252,0.0001677021,0.00008137775,0.0001295041,0.0001534167],"category_scores_gemma":[0.0002381399,0.0001550794,0.00005126791,0.0000885219,0.0001980157,0.00009896669,0.000094587,0.0001907287,0.000008309931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001633798,"about_ca_system_score_gemma":0.00002476702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005123112,"about_ca_topic_score_gemma":0.000005458085,"domain_scores_codex":[0.9989789,0.00006497445,0.0001319009,0.0004786576,0.0001224222,0.0002231638],"domain_scores_gemma":[0.9988459,0.0008658381,0.00004007006,0.0001355502,0.00002261593,0.00009003007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003695202,0.0001144455,0.001186155,0.0001210214,0.00007580555,0.00003821223,0.00005261818,0.000002359642,0.9207512,0.0003804406,0.0000960264,0.07714474],"study_design_scores_gemma":[0.0001345335,0.00003746257,0.01314365,0.0001289919,0.00005239209,0.00005403211,0.00005462731,0.005902411,0.9790532,0.0003113624,0.0008551435,0.0002721694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840168,0.001381384,0.01212926,0.0006116714,0.00002727392,0.00007853777,0.0001549168,0.0001241634,0.001475929],"genre_scores_gemma":[0.9976816,0.000252811,0.001842926,0.00005820142,0.00005213771,0.0000252495,0.000004569111,0.0000167818,0.00006572725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07687257,"threshold_uncertainty_score":0.6323954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923077619754588,"score_gpt":0.2545524270940637,"score_spread":0.2253216508965178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}