{"id":"W4396746795","doi":"10.3390/molecules29102200","title":"Novel Combretastatin A-4 Analogs—Design, Synthesis, and Antiproliferative and Anti-Tubulin Activity","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Tubulin; Combretastatin; Chemistry; Sulforhodamine B; Microtubule; Stereochemistry; Colchicine; In vitro; In vivo; Cytotoxicity; Biochemistry; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007477667,0.0002587242,0.0002655755,0.0002725722,0.0001165915,0.000171373,0.0003063061,0.0001819723,0.0009367379],"category_scores_gemma":[0.0001056563,0.00009612102,0.0001876737,0.0002033513,0.00009904472,0.0001710369,0.0001121149,0.000244542,0.0002973345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002892957,"about_ca_system_score_gemma":0.0002369306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006194967,"about_ca_topic_score_gemma":0.001255351,"domain_scores_codex":[0.999964,0.000006333173,0.000004074192,0.000009123457,0.000008947488,0.000007553268],"domain_scores_gemma":[0.9999626,0.000002605518,0.00001097673,0.000003349472,0.000007901468,0.00001265101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006337899,0.0003075304,0.0006001902,0.0003856234,0.00005626917,0.0003047268,0.00004501658,0.006789559,0.9479767,0.0009459071,0.0004304138,0.04152429],"study_design_scores_gemma":[0.0005614063,0.004755216,0.004040675,0.00003705635,0.0001727723,0.0008797217,0.00006481785,0.01583636,0.9152891,0.0004791878,0.05783765,0.00004607091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9713389,0.008440292,0.01294729,0.0001848304,0.00007323949,0.0003296823,0.0009538457,0.0001343715,0.005597526],"genre_scores_gemma":[0.9713175,0.005628197,0.01892729,0.0001163615,0.00002784238,0.0001256338,0.0008222896,0.00002506788,0.003009825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009367379,"threshold_uncertainty_score":0.003133714,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02923077619754588,"score_gpt":0.2545524270940637,"score_spread":0.2253216508965178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}