{"id":"W4396749398","doi":"10.1016/s2352-3018(24)00031-6","title":"Switch to fixed-dose doravirine (100 mg) with islatravir (0·75 mg) once daily in virologically suppressed adults with HIV-1 on antiretroviral therapy: 48-week results of a phase 3, randomised, open-label, non-inferiority trial","year":2024,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Merck Sharp and Dohme; Merck","keywords":"Medicine; Antiretroviral therapy; Human immunodeficiency virus (HIV); Pharmacology; Internal medicine; Pediatrics; Viral load; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00202076,0.002219321,0.00315409,0.0004599868,0.0004268261,0.001601611,0.001073246,0.002616395,0.009279154],"category_scores_gemma":[0.002197296,0.000745432,0.002893535,0.0004300142,0.001602037,0.002097081,0.0004506829,0.004830771,0.001867817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007737963,"about_ca_system_score_gemma":0.0006970815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152153,"about_ca_topic_score_gemma":0.002332377,"domain_scores_codex":[0.9991223,0.0004562027,0.0000478268,0.0001577185,0.00005409613,0.0001617532],"domain_scores_gemma":[0.9987809,0.0004991934,0.0001896389,0.0001118428,0.00004976111,0.0003685847],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9711019,0.004385497,0.0004632019,0.0004329337,0.0008399758,0.00004793513,0.00009794334,0.0003113957,0.002381775,0.00009107443,0.000706902,0.01913946],"study_design_scores_gemma":[0.9629468,0.03470466,0.00128915,0.00002331576,0.0002022067,0.00002563953,0.00002812991,0.0002107777,0.0001695917,0.0001237503,0.0002603653,0.00001570135],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896395,0.00377692,0.000513531,0.0008360222,0.0005684989,0.001209894,0.0009604074,0.0001820428,0.002313179],"genre_scores_gemma":[0.9887318,0.002344259,0.00137609,0.001623502,0.0004710896,0.001135633,0.001075893,0.00005194685,0.003189828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009279154,"threshold_uncertainty_score":0.03104186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04227587711414808,"score_gpt":0.3296904653911674,"score_spread":0.2874145882770193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}