{"id":"W4396749398","doi":"10.1016/s2352-3018(24)00031-6","title":"Switch to fixed-dose doravirine (100 mg) with islatravir (0·75 mg) once daily in virologically suppressed adults with HIV-1 on antiretroviral therapy: 48-week results of a phase 3, randomised, open-label, non-inferiority trial","year":2024,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Merck Sharp and Dohme; Merck","keywords":"Medicine; Antiretroviral therapy; Human immunodeficiency virus (HIV); Pharmacology; Internal medicine; Pediatrics; Viral load; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001094015,0.0005213459,0.001414767,0.0001995536,0.0001125617,0.0001264443,0.0005983404,0.0001295691,0.00008474791],"category_scores_gemma":[0.0001115594,0.0002653124,0.00008392182,0.0007884495,0.000171592,0.0001951426,0.0001348449,0.0005915037,0.000143954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001150027,"about_ca_system_score_gemma":0.0003661552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001458602,"about_ca_topic_score_gemma":0.0001348641,"domain_scores_codex":[0.9969347,0.0002362468,0.0007402951,0.0008204036,0.0006294121,0.0006389522],"domain_scores_gemma":[0.9981806,0.0004437867,0.0001914062,0.0008964603,0.00009703451,0.0001907653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9619176,0.003883205,0.002001379,0.0001160871,0.0004480124,0.001091143,0.004551953,0.0000211765,0.008749152,0.00006892453,0.008408532,0.008742852],"study_design_scores_gemma":[0.955589,0.01990105,0.005126117,0.001822309,0.0002562876,0.00004617074,0.0002190054,0.0009200062,0.006506818,0.00004327589,0.009043717,0.0005262566],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788348,0.0001661045,0.0001198494,0.0107516,0.0001432976,0.005173897,0.0002929322,0.000115596,0.004401887],"genre_scores_gemma":[0.9911767,0.0002359213,0.001741331,0.0006939234,0.0003787764,0.0004361245,0.0002622928,0.00006079516,0.005014131],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01601784,"threshold_uncertainty_score":0.9999799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04227587711414808,"score_gpt":0.3296904653911674,"score_spread":0.2874145882770193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}