{"id":"W4396750377","doi":"10.1101/2024.05.07.592891","title":"Repeated fasting events sensitize enhancers, transcription factor activity and gene expression to support augmented ketogenesis","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Azrieli Foundation; Israel Science Foundation; Agence Nationale de la Recherche; International Development Research Centre","keywords":"Ketogenesis; Enhancer; Endocrinology; Internal medicine; Transcription factor; Ketone bodies; Transcriptome; Biology; Transcription (linguistics); Gene; Gene expression; Medicine; Metabolism; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269148,0.000171694,0.0002039924,0.0001885756,0.000117328,0.0003660556,0.0001225781,0.0002052917,0.00290796],"category_scores_gemma":[0.0001060414,0.000149296,0.0001885055,0.0001035455,0.00030149,0.000181993,0.0002747432,0.0005334081,0.0004091858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001949882,"about_ca_system_score_gemma":0.00009913723,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002289699,"about_ca_topic_score_gemma":0.0004961816,"domain_scores_codex":[0.999892,0.000009234756,0.000007597897,0.00003689108,0.00002445205,0.00002980078],"domain_scores_gemma":[0.9999003,0.00001358727,0.00002916874,0.00001842042,0.000008240361,0.0000301987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001317441,0.00001384281,0.0004517282,0.00001581943,0.000002619307,0.00002986692,0.00001268704,0.00002700764,0.9982558,0.00007504027,0.000038486,0.0009453913],"study_design_scores_gemma":[0.00002334175,0.0002583914,0.04275402,0.00001286393,0.00001128642,0.0003483649,0.000103673,0.0006694237,0.9520226,0.0002900948,0.003494618,0.00001135061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947929,0.0007449324,0.00255357,0.0001121633,0.00005315913,0.000007896134,0.0004600989,0.0001070408,0.001168257],"genre_scores_gemma":[0.993485,0.0002637482,0.002019666,0.00007450337,0.00001722325,0.00001568288,0.0004800947,0.00004800881,0.003596054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00290796,"threshold_uncertainty_score":0.009728074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02321804046639504,"score_gpt":0.2600145661967816,"score_spread":0.2367965257303866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}