{"id":"W4396763397","doi":"10.1101/2024.05.07.592317","title":"Label-free 3D subcellular phenotyping of mouse embryos by holotomography enables early prediction of blastocyst formation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kootenay Association for Science & Technology","funders":"","keywords":"Blastocyst; Embryo; Cell biology; Subcellular localization; Andrology; Computer science; Embryogenesis; Artificial intelligence; Biology; Cytoplasm; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004913641,0.000510373,0.0003076656,0.0005136781,0.000155153,0.0007210699,0.0003478644,0.0006078546,0.001125708],"category_scores_gemma":[0.0006236726,0.0002656907,0.0002329037,0.0002609688,0.0003841869,0.0003594238,0.0003749306,0.0005384909,0.0005053713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002999064,"about_ca_system_score_gemma":0.0003024954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078259,"about_ca_topic_score_gemma":0.002136427,"domain_scores_codex":[0.9998747,0.00002206136,0.000007679119,0.00003926903,0.00004309833,0.00001312659],"domain_scores_gemma":[0.9996798,0.0001215111,0.00008665998,0.00004919195,0.00004279482,0.00002005895],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007592994,0.00001823047,0.004121851,0.00008733926,0.00002145841,0.00006159781,0.00003222769,0.006205348,0.9718056,0.00057269,0.0003292378,0.01666849],"study_design_scores_gemma":[0.0000111723,0.0001129282,0.04145325,0.00003606465,0.00003715982,0.0002947254,0.00006037498,0.2392765,0.7142117,0.001928495,0.002530731,0.00004687971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4587926,0.001150973,0.5318669,0.0002273107,0.00004364785,0.00006411073,0.002546501,0.002842773,0.002465193],"genre_scores_gemma":[0.8000922,0.001180831,0.1944809,0.00009256364,0.00002571532,0.0001200437,0.001637652,0.0002400156,0.002130046],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001125708,"threshold_uncertainty_score":0.003765821,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006562342765707331,"score_gpt":0.2000354290709611,"score_spread":0.1934730863052538,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}