{"id":"W4396766573","doi":"10.1007/s40263-024-01090-3","title":"FcRn Inhibitor Therapies in Neurologic Diseases","year":2024,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Immunology; Neonatal Fc receptor; Adverse effect; Myelin oligodendrocyte glycoprotein; Intravenous Immunoglobulin Therapy; Antibody; Myasthenia gravis; Clinical trial; Multiple sclerosis; Neuromyelitis optica; Immunoglobulin G; Pharmacology; Internal medicine; Experimental autoimmune encephalomyelitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877311,0.0004208102,0.000518624,0.0007220464,0.0002825274,0.0005349172,0.0003373504,0.0006129535,0.004128208],"category_scores_gemma":[0.0003706241,0.00006767351,0.0003058588,0.0004162196,0.000285574,0.0003830461,0.0002416494,0.0008381084,0.0007046594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009055462,"about_ca_system_score_gemma":0.0009084296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0020705,"about_ca_topic_score_gemma":0.006582057,"domain_scores_codex":[0.9998999,0.00002302688,0.00001201649,0.00001051822,0.00002756632,0.0000269797],"domain_scores_gemma":[0.9998472,0.00005389029,0.0000377436,0.000005419837,0.00003390259,0.00002185011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001498465,0.0004532349,0.001229399,0.001832011,0.0001771868,0.0009006884,0.0000479615,0.00065942,0.01268705,0.007503271,0.02416718,0.9488441],"study_design_scores_gemma":[0.001675811,0.006699173,0.02187043,0.004877616,0.001085339,0.009172438,0.000212,0.001803518,0.0285077,0.01233839,0.9117,0.00005754648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02654669,0.9429356,0.0009554586,0.00430583,0.0009536357,0.00003219295,0.000128371,0.00005491289,0.02408734],"genre_scores_gemma":[0.1750663,0.8012708,0.002822064,0.003280102,0.001658999,0.00009128423,0.0002906615,0.00001394849,0.01550586],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004128208,"threshold_uncertainty_score":0.01381028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946845933593197,"score_gpt":0.3168302589198834,"score_spread":0.2973617995839514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}