{"id":"W4396766573","doi":"10.1007/s40263-024-01090-3","title":"FcRn Inhibitor Therapies in Neurologic Diseases","year":2024,"lang":"en","type":"article","venue":"CNS Drugs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Medicine; Immunology; Neonatal Fc receptor; Adverse effect; Myelin oligodendrocyte glycoprotein; Intravenous Immunoglobulin Therapy; Antibody; Myasthenia gravis; Clinical trial; Multiple sclerosis; Neuromyelitis optica; Immunoglobulin G; Pharmacology; Internal medicine; Experimental autoimmune encephalomyelitis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008436984,0.0001029228,0.0001590855,0.0001493999,0.00003485612,0.00003644428,0.00007221816,0.00004415485,0.0005009351],"category_scores_gemma":[0.0000358042,0.00006829878,0.00009097924,0.0002469092,0.0001079086,0.0000540905,0.00005682336,0.0002463251,0.0004206944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002286908,"about_ca_system_score_gemma":0.00008253824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000515489,"about_ca_topic_score_gemma":0.000005487748,"domain_scores_codex":[0.9991328,0.00003815266,0.0001312883,0.0002220058,0.0002289861,0.0002467623],"domain_scores_gemma":[0.9995916,0.0001412222,0.000007378381,0.0001274406,0.00002045231,0.0001118913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002705949,0.001453475,0.4617313,0.003388298,0.0003635418,0.009233907,0.01012381,0.00001804482,0.03848023,0.02928066,0.09776917,0.3454517],"study_design_scores_gemma":[0.0009723912,0.0006775231,0.3719376,0.0003509987,0.00005978501,0.0001147426,0.0005095064,0.001684374,0.001879865,0.006165375,0.6153319,0.00031595],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9650854,0.01288799,0.000002314705,0.01243256,0.0002202388,0.0001689052,0.00002317143,0.0001036886,0.009075727],"genre_scores_gemma":[0.9879643,0.0005244034,0.00002866478,0.001009501,0.0004354131,0.00002339847,0.00002118125,0.00001527485,0.009977897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5175627,"threshold_uncertainty_score":0.5484889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946845933593197,"score_gpt":0.3168302589198834,"score_spread":0.2973617995839514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}