{"id":"W4396776045","doi":"10.1016/s2468-1253(24)00091-8","title":"Clinical significance of combined tumour-infiltrating lymphocytes and microsatellite instability status in colorectal cancer: a systematic review and network meta-analysis","year":2024,"lang":"en","type":"review","venue":"˜The œLancet. Gastroenterology & hepatology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft","keywords":"Microsatellite instability; Colorectal cancer; Oncology; Medicine; Meta-analysis; Internal medicine; Cancer; Tumor-infiltrating lymphocytes; DNA mismatch repair; Biology; Microsatellite; Immunotherapy; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.003842545,0.0007753762,0.01952289,0.0002798929,0.00007809159,0.0000281326,0.0003762295,0.0004733886,0.0000703405],"category_scores_gemma":[0.0001480775,0.000464048,0.002218588,0.0009878663,0.001401094,0.00003854271,0.0002194326,0.001048556,0.000002583983],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002604025,"about_ca_system_score_gemma":0.0005256641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007105291,"about_ca_topic_score_gemma":0.006166881,"domain_scores_codex":[0.9902714,0.003747291,0.003690059,0.001126128,0.0002002606,0.0009647941],"domain_scores_gemma":[0.9957063,0.001421993,0.001790498,0.0008002177,0.0001184938,0.0001624771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0019496,0.000160559,0.117771,0.7217534,0.1527153,0.0001080467,0.00009997407,9.481536e-7,0.000008842449,0.0000132546,0.0003611064,0.005057961],"study_design_scores_gemma":[0.002775456,0.001609732,0.003868148,0.04590638,0.9312206,0.0009660365,0.00003440526,0.0001508341,0.00000136763,0.00002946109,0.01302448,0.0004130956],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01057593,0.9840089,0.00001429739,0.000741702,0.000271253,0.004001075,0.0003355925,0.00003994288,0.00001128286],"genre_scores_gemma":[0.01959682,0.9764013,0.0001501558,0.002143826,0.0001159948,0.001422435,0.00009957072,0.00005001214,0.00001991046],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7785053,"threshold_uncertainty_score":0.9997811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07815559779266261,"score_gpt":0.3724368671029222,"score_spread":0.2942812693102596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}