{"id":"W4396791723","doi":"10.1016/j.radonc.2024.110326","title":"Detection of FLASH-radiotherapy tissue sparing in a 3D-spheroid model using DNA damage response markers","year":2024,"lang":"en","type":"article","venue":"Radiotherapy and Oncology","topic":"Radiation Therapy and Dosimetry","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Centre for Applied Research in Cancer Control; Spinal Cord Injury BC","funders":"Canadian Institutes of Health Research","keywords":"Flash (photography); Spheroid; DNA damage; Radiation therapy; Irradiation; DNA; Cancer research; Chemistry; Pathology; Biology; Medicine; Internal medicine; Optics; Genetics; Physics; Biochemistry; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002108248,0.0003247255,0.0002476226,0.0002913659,0.0001228101,0.0004028551,0.0002340017,0.0005376201,0.001134902],"category_scores_gemma":[0.0002569459,0.0002346286,0.0002721754,0.0002758524,0.0002436179,0.0002881852,0.000234489,0.0003310763,0.0002434881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003231927,"about_ca_system_score_gemma":0.0004727605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002032546,"about_ca_topic_score_gemma":0.001797183,"domain_scores_codex":[0.9999235,0.000006736097,0.000003442575,0.0000236273,0.00003197178,0.00001078521],"domain_scores_gemma":[0.9998078,0.00006421447,0.00004473472,0.00003059371,0.00003004109,0.00002275875],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002237507,0.00004712473,0.001430918,0.00008336023,0.00001285378,0.0001770464,0.0001115647,0.01727119,0.9766773,0.0002405043,0.0001239683,0.003600407],"study_design_scores_gemma":[0.00002795435,0.0003478102,0.009600578,0.00001085015,0.00004517897,0.0002575823,0.00009729618,0.09072775,0.8971059,0.0001877638,0.001558047,0.00003340393],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9288731,0.0006370646,0.06774133,0.00008646677,0.00003324593,0.0000647432,0.0006250042,0.0005726215,0.001366546],"genre_scores_gemma":[0.9764389,0.000419537,0.02098653,0.00003366844,0.00000296024,0.00005681249,0.0003505521,0.00005635693,0.001654707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002032546,"threshold_uncertainty_score":0.004041374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033974506295523,"score_gpt":0.3286715037007799,"score_spread":0.3083317586378247,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}