{"id":"W4396798116","doi":"10.3390/vaccines12050524","title":"Optimization of Culture Media and Feeding Strategy for High Titer Production of an Adenoviral Vector in HEK 293 Fed-Batch Culture","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Titer; Cell culture; Viral vector; Fed-batch culture; Biology; Bioreactor; Biotechnology; HEK 293 cells; Productivity; Biomanufacturing; Virology; Virus; Food science; Recombinant DNA; Biochemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005255238,0.00009135131,0.0001054045,0.00004586462,0.00002573181,0.00002115941,0.00004455336,0.0001103167,0.00001108931],"category_scores_gemma":[0.00005135521,0.00006972157,0.00003521112,0.0001046042,0.00001390214,0.00001750355,0.00002087506,0.00003911447,1.481312e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005006026,"about_ca_system_score_gemma":0.0000229295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003055753,"about_ca_topic_score_gemma":0.00004619737,"domain_scores_codex":[0.9994662,0.00001789193,0.0001558796,0.0002251272,0.00005134924,0.00008355368],"domain_scores_gemma":[0.9997347,0.000004339595,0.00004844215,0.00009068439,0.00009303647,0.00002881579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002593142,0.00008510077,0.001398962,0.0003888176,0.00003743596,8.553503e-7,0.0005259456,0.008153905,0.9820041,0.0001618654,0.00571179,0.001271906],"study_design_scores_gemma":[0.001013095,0.001830451,0.008536664,0.0002773469,0.00007668918,0.00001727318,0.0005945944,0.003326402,0.9814469,0.0009981648,0.0015685,0.0003139305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996193,0.002638591,0.0003903585,0.0000804934,0.0004157429,0.0001908922,0.00004565629,0.00001149618,0.00003378901],"genre_scores_gemma":[0.9978598,0.0003410637,0.0007916128,0.00001269655,0.0004552034,0.00002397431,0.0002392647,0.00001284772,0.0002635591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007137702,"threshold_uncertainty_score":0.2843163,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012623534061484,"score_gpt":0.270514297715478,"score_spread":0.2603880623748632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}