{"id":"W4396798116","doi":"10.3390/vaccines12050524","title":"Optimization of Culture Media and Feeding Strategy for High Titer Production of an Adenoviral Vector in HEK 293 Fed-Batch Culture","year":2024,"lang":"en","type":"article","venue":"Vaccines","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Titer; Cell culture; Viral vector; Fed-batch culture; Biology; Bioreactor; Biotechnology; HEK 293 cells; Productivity; Biomanufacturing; Virology; Virus; Food science; Recombinant DNA; Biochemistry; Botany","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0011257,0.0009744267,0.00107569,0.0007142829,0.000422489,0.001121596,0.0009430593,0.0007412685,0.0007854814],"category_scores_gemma":[0.0008001538,0.0003490412,0.0006907965,0.0006804182,0.0002407868,0.0005585656,0.0005330332,0.001085984,0.00099096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006256525,"about_ca_system_score_gemma":0.0005482229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002192496,"about_ca_topic_score_gemma":0.003020148,"domain_scores_codex":[0.999203,0.0001166545,0.0001484782,0.0001790141,0.000271012,0.0000817625],"domain_scores_gemma":[0.9996319,0.0000909663,0.00005951152,0.00003513002,0.00013828,0.00004428767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000111371,0.0001514212,0.000389716,0.0001493267,0.00001354222,0.000104491,0.000052584,0.0005402395,0.994726,0.00008396835,0.0001548219,0.003522537],"study_design_scores_gemma":[0.00001252172,0.0003049079,0.001196316,0.00002871895,0.00004979432,0.0001222096,0.00005755457,0.002096025,0.9927625,0.00003409237,0.003300665,0.00003461251],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9186211,0.003950751,0.06517477,0.0003670076,0.0004092355,0.001529561,0.003233175,0.0008775014,0.005836871],"genre_scores_gemma":[0.7142389,0.00587686,0.2599213,0.0002731278,0.00009216748,0.002046294,0.008562039,0.0003805176,0.008608908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002192496,"threshold_uncertainty_score":0.005953312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01012623534061484,"score_gpt":0.270514297715478,"score_spread":0.2603880623748632,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}