{"id":"W4396800153","doi":"10.1107/s2053273323086758","title":"CD4<sup>+</sup> T cell recognition of a highly conserved bacterial epitope of pneumolysin presented by a broadly expressed HLA allotype","year":2023,"lang":"en","type":"article","venue":"Acta Crystallographica Section A Foundations and Advances","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Allotype; Pneumolysin; Epitope; Human leukocyte antigen; Biology; Genetics; Computational biology; Virology; Molecular biology; Gene; Antigen; Bacterial protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007772214,0.0003597097,0.0002107687,0.0001374446,0.0001245912,0.0003164785,0.0001420907,0.0003662348,0.006151164],"category_scores_gemma":[0.00009738953,0.00009293282,0.0001104236,0.00009031579,0.0001918111,0.0001576935,0.0001659272,0.0004620424,0.001325883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001326133,"about_ca_system_score_gemma":0.0001004579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002388815,"about_ca_topic_score_gemma":0.0002886827,"domain_scores_codex":[0.9999084,0.00001401419,0.000006027476,0.00003275184,0.00001391187,0.00002470654],"domain_scores_gemma":[0.999956,0.000009623303,0.00000898348,0.000004511698,0.000005006168,0.00001595731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000323242,0.00009884938,0.004113608,0.00009614723,0.000009716769,0.0006145384,0.00005862706,0.0001726894,0.9817822,0.0001814296,0.0006821192,0.01186688],"study_design_scores_gemma":[0.0003520725,0.009257145,0.2356631,0.0001677028,0.0001945388,0.01958115,0.000978342,0.01145243,0.6652498,0.001518655,0.05553532,0.00004965195],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882708,0.001593101,0.001644474,0.0002657943,0.00007876701,0.00005952033,0.0003875475,0.0001133863,0.00758673],"genre_scores_gemma":[0.9894633,0.0005221307,0.00129741,0.0003180209,0.0001250291,0.0000428227,0.0004445348,0.0000183019,0.007768405],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006151164,"threshold_uncertainty_score":0.02057773,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01744575794511582,"score_gpt":0.2626796330362248,"score_spread":0.2452338750911089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}