{"id":"W4396813866","doi":"10.1016/j.immuni.2024.04.015","title":"Structural transitions enable interleukin-18 maturation and signaling","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; eNeura Therapeutics; Boehringer Ingelheim Fonds; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Science; National Institutes of Health; Biological and Environmental Research; National Natural Science Foundation of China; National Institute of General Medical Sciences; Charles A. King Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Inflammasome; Caspase 1; Caspase; Cleavage (geology); Biology; Cell biology; Signaling proteins; Binding site; Conformational change; Signal transduction; Biophysics; Receptor; Apoptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007482478,0.00007421927,0.00005181725,0.00002934724,0.0001206566,0.00007024067,0.00005720185,0.00006171662,0.00009185452],"category_scores_gemma":[0.00001190499,0.00006870889,0.00004048279,0.00005037656,0.00004516252,0.00001018477,0.00003002125,0.0001049926,0.000007763396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005865823,"about_ca_system_score_gemma":0.00002591291,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004248972,"about_ca_topic_score_gemma":0.00002092713,"domain_scores_codex":[0.9996247,0.00003577145,0.00009236578,0.0001091248,0.00003465504,0.0001033401],"domain_scores_gemma":[0.9998162,0.000005633043,0.0000107022,0.000124586,0.00002586602,0.00001705311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003155024,0.000004328102,0.00003571082,0.0000297903,0.00003649973,0.000001641636,0.0004360539,0.00002790646,0.9950686,0.000174645,0.0004617051,0.00369156],"study_design_scores_gemma":[0.0003713132,0.0002026042,0.001957967,0.00006695087,0.00003990503,0.00005723178,0.001553558,0.001080437,0.9619951,0.001319318,0.03106609,0.0002895318],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941654,0.003043339,0.0004034475,0.0001387066,0.0001711217,0.0000647419,0.00001036859,0.00002123762,0.00198167],"genre_scores_gemma":[0.9989555,0.00007950808,0.0001101175,0.0000707677,0.00006561409,0.000005934543,0.0002148911,0.000009626401,0.0004880563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03307351,"threshold_uncertainty_score":0.2801867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039582503108163,"score_gpt":0.2488196363890836,"score_spread":0.238423811358002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}