{"id":"W4396813866","doi":"10.1016/j.immuni.2024.04.015","title":"Structural transitions enable interleukin-18 maturation and signaling","year":2024,"lang":"en","type":"article","venue":"Immunity","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; eNeura Therapeutics; Boehringer Ingelheim Fonds; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; Office of Science; National Institutes of Health; Biological and Environmental Research; National Natural Science Foundation of China; National Institute of General Medical Sciences; Charles A. King Trust; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Inflammasome; Caspase 1; Caspase; Cleavage (geology); Biology; Cell biology; Signaling proteins; Binding site; Conformational change; Signal transduction; Biophysics; Receptor; Apoptosis; Biochemistry; Programmed cell death","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938069,0.0002643656,0.0002024608,0.00009889022,0.000449538,0.0006381359,0.0003184294,0.0006608989,0.003905252],"category_scores_gemma":[0.0004480747,0.0001961538,0.000219714,0.00008920844,0.0006049149,0.001078695,0.0004828073,0.001400318,0.001058312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003052715,"about_ca_system_score_gemma":0.0002077749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238078,"about_ca_topic_score_gemma":0.0001424827,"domain_scores_codex":[0.9999005,0.0000177009,0.000006383535,0.00002253313,0.00001981964,0.00003306951],"domain_scores_gemma":[0.9998287,0.00003756838,0.00004699815,0.00002569075,0.00001830299,0.00004275917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004963587,0.00008090385,0.0008776346,0.00009903013,0.00001594989,0.0008057365,0.000151868,0.001107365,0.9467411,0.04246362,0.001068354,0.00609216],"study_design_scores_gemma":[0.000097456,0.0004225523,0.002995927,0.00003203479,0.00001769658,0.001653193,0.0003043826,0.003950959,0.9302787,0.02694774,0.03326119,0.00003816235],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613528,0.002704031,0.02204099,0.002732225,0.0006955547,0.00003663709,0.0002612305,0.0004819083,0.009694519],"genre_scores_gemma":[0.9939684,0.0006248677,0.00270898,0.0003121097,0.00005140603,0.00001825817,0.0001480844,0.00005429584,0.002113633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003905252,"threshold_uncertainty_score":0.01306444,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039582503108163,"score_gpt":0.2488196363890836,"score_spread":0.238423811358002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}