{"id":"W4396832529","doi":"10.1093/toxsci/kfae063","title":"Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of <i>Danio rerio</i> to bisphenol A and tetrabromobisphenol A","year":2024,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; National Research Council Canada","funders":"National Research Council Canada","keywords":"Danio; Zebrafish; Transcriptome; Toxicodynamics; Adverse Outcome Pathway; Toxicogenomics; Computational biology; Biology; Tetrabromobisphenol A; Model organism; Organism; Toxicology; Bioinformatics; Genetics; Toxicokinetics; Gene; Chemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001679066,0.0001476317,0.0003908347,0.00006836015,0.0001066405,0.0000395889,0.000255296,0.0001357409,0.00001447598],"category_scores_gemma":[0.00007842861,0.00008781403,0.00009478879,0.000598632,0.0009885004,0.00000970883,0.0001571545,0.00007656039,7.729442e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003134805,"about_ca_system_score_gemma":0.0002992797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000331611,"about_ca_topic_score_gemma":0.00003181119,"domain_scores_codex":[0.9978444,0.0006190097,0.0004039161,0.0004514599,0.0004883783,0.0001928404],"domain_scores_gemma":[0.9993938,0.00007208469,0.0001475218,0.0001805822,0.0001191558,0.0000869176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00004969567,0.0001738797,0.005721137,0.00004926698,0.00005801945,2.897377e-7,0.0002670166,0.01087829,0.9817827,0.0005062577,0.00002291688,0.000490477],"study_design_scores_gemma":[0.001471095,0.009434103,0.2777111,0.0003878823,0.001628345,0.00009115092,0.008673232,0.3626895,0.33619,0.0005105127,0.0003858563,0.0008272562],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995089,0.00305317,0.000797163,0.00005061341,0.00007231766,0.0006942616,0.00002555877,0.000006400904,0.0002115202],"genre_scores_gemma":[0.997493,0.00002907107,0.002371442,0.00002031179,0.00001927847,0.0000466147,0.000001718631,0.000004312592,0.0000142966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6455927,"threshold_uncertainty_score":0.3642171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1402269019554355,"score_gpt":0.4004167432083533,"score_spread":0.2601898412529178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}