{"id":"W4396832529","doi":"10.1093/toxsci/kfae063","title":"Comparative toxicological assessment of 2 bisphenols using a systems approach: evaluation of the behavioral and transcriptomic responses of <i>Danio rerio</i> to bisphenol A and tetrabromobisphenol A","year":2024,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Gene Regulatory Network Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Canada; National Research Council Canada","funders":"National Research Council Canada","keywords":"Danio; Zebrafish; Transcriptome; Toxicodynamics; Adverse Outcome Pathway; Toxicogenomics; Computational biology; Biology; Tetrabromobisphenol A; Model organism; Organism; Toxicology; Bioinformatics; Genetics; Toxicokinetics; Gene; Chemistry; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002497985,0.00058976,0.0002971551,0.0004705958,0.0002606696,0.0003656613,0.0002559608,0.0005127608,0.0008586355],"category_scores_gemma":[0.0001957553,0.0001996918,0.0004801642,0.0002677255,0.0003926007,0.0002755225,0.0003518241,0.0004452456,0.0001794652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006809491,"about_ca_system_score_gemma":0.0005691919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004306894,"about_ca_topic_score_gemma":0.007462356,"domain_scores_codex":[0.9997349,0.00004059049,0.00002167508,0.00006762828,0.0001022248,0.00003284032],"domain_scores_gemma":[0.9998311,0.00002685517,0.00005018096,0.00001795803,0.00005296467,0.00002093231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002619693,0.000008803397,0.0002157186,0.00001765888,0.000005831606,0.000006445182,0.000007693904,0.00008043707,0.9993398,0.00001123763,0.000007244489,0.0002729601],"study_design_scores_gemma":[0.000005541361,0.0007409545,0.01253596,0.000004432041,0.00004474534,0.00004257883,0.0000666312,0.0008493518,0.9850959,0.00003998076,0.0005605826,0.00001335238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891437,0.0004016271,0.007800524,0.00007319065,0.0000237625,0.0001422008,0.001325123,0.00007535635,0.001014425],"genre_scores_gemma":[0.9788646,0.001412465,0.01341926,0.0001749947,0.00001188596,0.0004769733,0.002054331,0.0000312902,0.003554154],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004306894,"threshold_uncertainty_score":0.008563638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1402269019554355,"score_gpt":0.4004167432083533,"score_spread":0.2601898412529178,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}