{"id":"W4396834423","doi":"10.1021/acs.biochem.4c00044","title":"Development of Peptide Displacement Assays to Screen for Antagonists of DDB1 Interactions","year":2024,"lang":"en","type":"article","venue":"Biochemistry","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Ontario Institute for Cancer Research; University of Toronto","funders":"Government of Ontario","keywords":"DDB1; Peptide; Ubiquitin; Chemistry; DNA-binding protein; Proteasome; Biochemistry; Ubiquitin ligase; Cell biology; Biology; Molecular biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001045525,0.002201634,0.001204156,0.0008230602,0.0003483692,0.0005108998,0.001307592,0.001307261,0.002329886],"category_scores_gemma":[0.000831825,0.0008424745,0.0005476886,0.0006438172,0.0003704132,0.0004464509,0.0005417133,0.002148525,0.001332912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006429119,"about_ca_system_score_gemma":0.0003148369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003805618,"about_ca_topic_score_gemma":0.0009727844,"domain_scores_codex":[0.9986766,0.000304342,0.00009276553,0.0002917568,0.0004573803,0.0001771871],"domain_scores_gemma":[0.9992716,0.0002921155,0.0001127811,0.0000558074,0.000162412,0.0001053031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005499228,0.00009481067,0.00005755885,0.00006090092,0.00001193995,0.00001753555,0.00001078377,0.0001937279,0.9975905,0.00004494027,0.00006603637,0.001796316],"study_design_scores_gemma":[0.00003675056,0.0006854718,0.0005708467,0.000007620868,0.00001944513,0.0001477808,0.00001647963,0.002898642,0.9937503,0.00004784622,0.001803492,0.00001533971],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.707681,0.008050476,0.2687766,0.0007878005,0.0002982353,0.002349306,0.002861958,0.001316325,0.007878355],"genre_scores_gemma":[0.6804718,0.006590693,0.2872464,0.0006763575,0.0001253626,0.003681461,0.007272406,0.0002306042,0.0137049],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002329886,"threshold_uncertainty_score":0.007794261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01538499486191649,"score_gpt":0.3050161683984207,"score_spread":0.2896311735365042,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}