{"id":"W4396854062","doi":"10.1016/j.actbio.2024.05.021","title":"Sensory neurons increase keratinocyte proliferation through CGRP release in a tissue engineered in vitro model of innervation in psoriasis","year":2024,"lang":"en","type":"article","venue":"Acta Biomaterialia","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Keratinocyte; Psoriasis; Calcitonin gene-related peptide; Epidermis (zoology); Pathology; Medicine; Neuropeptide; Cell biology; Biology; In vitro; Immunology; Anatomy; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002223636,0.0003376361,0.0003151589,0.0002796361,0.0002122667,0.0003232186,0.0001968503,0.0004083897,0.001058843],"category_scores_gemma":[0.0001009495,0.0001815645,0.0004150055,0.0002046097,0.000184684,0.0001912242,0.0002293691,0.0006859913,0.0004886141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000189384,"about_ca_system_score_gemma":0.0001533112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005766508,"about_ca_topic_score_gemma":0.001036641,"domain_scores_codex":[0.9996687,0.00005863189,0.00003773535,0.00005061293,0.0001453843,0.00003893287],"domain_scores_gemma":[0.9998631,0.00002816007,0.00002726418,0.00003336039,0.00001554904,0.00003250773],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006182645,0.00007009142,0.00006626611,0.0000360559,0.000003992514,0.00007161823,0.00001657871,0.00007765638,0.9991326,0.00002297316,0.00001823756,0.0004221158],"study_design_scores_gemma":[0.00002337918,0.0006256895,0.003745617,0.00001200811,0.0000300255,0.0004814198,0.00004982305,0.001297452,0.992327,0.00003325175,0.001367727,0.000006410558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900121,0.001499454,0.005481339,0.00007915677,0.0001021941,0.00008796065,0.0003401529,0.00007948023,0.002318087],"genre_scores_gemma":[0.9903917,0.001048331,0.005582741,0.00005629648,0.0000136757,0.00008114745,0.0003467616,0.00001554423,0.002463803],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001058843,"threshold_uncertainty_score":0.003542185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404060706872864,"score_gpt":0.2849768641709703,"score_spread":0.2609362571022417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}