{"id":"W4396863440","doi":"10.1002/iub.2826","title":"Delivery of <scp>AKT1</scp> phospho‐forms to human cells reveals differential substrate selectivity","year":2024,"lang":"en","type":"article","venue":"IUBMB Life","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Phosphorylation; AKT1; HEK 293 cells; Biology; Kinase; Cell biology; Serine; Protein kinase B; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001814323,0.0002530268,0.0001734103,0.00009902659,0.00009810548,0.0003196567,0.0001464184,0.0002782078,0.001208221],"category_scores_gemma":[0.00008603535,0.0001156546,0.0001981899,0.0001441273,0.0001693977,0.0001256321,0.000117759,0.0004156645,0.0004224064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002883631,"about_ca_system_score_gemma":0.0001467634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005794656,"about_ca_topic_score_gemma":0.0004158843,"domain_scores_codex":[0.9998457,0.00002362575,0.00001635286,0.00004039248,0.00004074447,0.00003309938],"domain_scores_gemma":[0.9999396,0.00001866223,0.00001741444,0.000008870828,0.000006472273,0.000009057987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006904732,0.00001223391,0.00004926464,0.00001664642,0.000003842584,0.00002370581,0.000009265481,0.00009136813,0.999054,0.00009919127,0.00004628338,0.0005251117],"study_design_scores_gemma":[0.000009875499,0.0001100837,0.0005153955,0.000001933244,0.000007971473,0.000127899,0.000006870672,0.0005631319,0.9970118,0.000016573,0.001626392,0.000002130783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915665,0.0007917157,0.004672157,0.0001119448,0.00002722616,0.00003878033,0.0006723432,0.0001002971,0.00201907],"genre_scores_gemma":[0.9943243,0.0004594907,0.002812963,0.00005496225,0.000006438125,0.00002834107,0.0006163954,0.00003023773,0.001666976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001208221,"threshold_uncertainty_score":0.00404191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007759281473004205,"score_gpt":0.2724062684388722,"score_spread":0.264646986965868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}