{"id":"W4396869146","doi":"10.1007/s12311-024-01701-1","title":"Driving Mitochondrial Fission Improves Cognitive, but not Motor Deficits in a Mouse Model of Ataxia of Charlevoix-Saguenay","year":2024,"lang":"en","type":"article","venue":"The Cerebellum","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health","keywords":"Mitochondrial fission; mitochondrial fusion; Mitochondrion; Biology; Ataxia; DNM1L; Neuroscience; Gene; Genetics; Cell biology; Mitochondrial DNA","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003771813,0.001336941,0.0008524395,0.001506571,0.0005768937,0.0006363067,0.0008103294,0.001430435,0.002871588],"category_scores_gemma":[0.0003624207,0.0002897346,0.00050502,0.0004850969,0.00102268,0.0007005912,0.0005851575,0.001387713,0.0004257261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008773232,"about_ca_system_score_gemma":0.0007410555,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003522085,"about_ca_topic_score_gemma":0.006650383,"domain_scores_codex":[0.9996997,0.00003585397,0.00004275917,0.00007684094,0.00007323101,0.00007171871],"domain_scores_gemma":[0.9995288,0.00005021777,0.0001652073,0.00004044072,0.00004335934,0.0001719377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001495773,0.0003254232,0.0003981206,0.0001217762,0.0000573172,0.0003987666,0.0000708247,0.000399095,0.9918405,0.0007549334,0.0003171574,0.003820182],"study_design_scores_gemma":[0.0004143096,0.002261568,0.00599688,0.00007780498,0.0001810971,0.0008728254,0.0002626655,0.003244697,0.9788425,0.0008559622,0.00693858,0.00005106845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926306,0.001196411,0.002842548,0.0005356247,0.000149918,0.00005494115,0.0007826418,0.0005478392,0.001259457],"genre_scores_gemma":[0.9910979,0.001029336,0.001806423,0.0001131597,0.00002522417,0.00008299106,0.0006522153,0.0001314647,0.005061339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003522085,"threshold_uncertainty_score":0.009606481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03166334487914668,"score_gpt":0.2622932083476444,"score_spread":0.2306298634684977,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}