{"id":"W4396869444","doi":"10.20944/preprints202405.0678.v1","title":"Reprogramming of Energy Metabolism in Human <em>PKD1</em> Polycystic Kidney Disease: A Systems Biology Analysis","year":2024,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; University Health Network","funders":"","keywords":"Mitochondrial biogenesis; PKD1; Biology; Polycystic kidney disease; Autosomal dominant polycystic kidney disease; Endocrinology; Lactate dehydrogenase A; Citric acid cycle; Mitochondrion; Warburg effect; Internal medicine; Pyruvate dehydrogenase complex; Glycolysis; Kidney; Cell biology; Metabolism; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002551141,0.0002326143,0.0004002478,0.0003590974,0.0001858205,0.0003863561,0.0001706393,0.0001610516,0.0006615408],"category_scores_gemma":[0.0001682831,0.00008614996,0.0003284778,0.0003709391,0.0003627892,0.000165448,0.0002356008,0.0001971401,0.00007679723],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006401147,"about_ca_system_score_gemma":0.000238416,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398714,"about_ca_topic_score_gemma":0.001188964,"domain_scores_codex":[0.999886,0.00002676643,0.000007759382,0.00004268006,0.00002594564,0.00001082062],"domain_scores_gemma":[0.9999455,0.00002036824,0.00001497046,0.000007876491,0.000005168362,0.000006044669],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001044005,0.0001276797,0.01626853,0.0003515686,0.0001020361,0.0003659293,0.0001134716,0.006680797,0.9635959,0.001016196,0.000191144,0.01014275],"study_design_scores_gemma":[0.00008889737,0.001191137,0.2103812,0.0000335463,0.0002238382,0.002108202,0.000279281,0.05529577,0.7221547,0.002501298,0.005681673,0.00006049009],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916816,0.001275426,0.005419687,0.00006660444,0.00001025391,0.00002487832,0.000950671,0.00004489193,0.0005259881],"genre_scores_gemma":[0.9945247,0.0005299365,0.003431864,0.00001577374,0.000003800495,0.0000274066,0.001236032,0.000004175098,0.0002262758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398714,"threshold_uncertainty_score":0.004644334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02862131826719125,"score_gpt":0.3039796525514706,"score_spread":0.2753583342842793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}