{"id":"W4396871343","doi":"10.1038/s41467-024-47106-w","title":"A cell-free nutrient-supplemented perfusate allows four-day ex vivo metabolic preservation of human kidneys","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"Hospital for Sick Children; Novo Nordisk Fonden; Leids Universitair Medisch Centrum; Novo Nordisk; Nierstichting","keywords":"Ex vivo; In vivo; Nutrient; Cell; Cell biology; Biology; Chemistry; Biochemistry; Biotechnology; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003301911,0.0003455385,0.0002956889,0.0002910561,0.0003354947,0.0005516328,0.0003363635,0.0003517699,0.001497207],"category_scores_gemma":[0.0002787928,0.0001449221,0.0002318517,0.0001828941,0.0003895452,0.0003819054,0.0003835656,0.0006210136,0.000401929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002292834,"about_ca_system_score_gemma":0.0005490983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00034699,"about_ca_topic_score_gemma":0.001019953,"domain_scores_codex":[0.9998486,0.00002554373,0.00001309184,0.00004632678,0.00004659511,0.00001977829],"domain_scores_gemma":[0.9998622,0.0000298487,0.00003798937,0.00002563725,0.00002011683,0.00002413745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009851038,0.00002220064,0.0002098578,0.00004117088,0.000004073593,0.00005053775,0.00002302016,0.0001180767,0.9968805,0.0001533253,0.00005374495,0.002345],"study_design_scores_gemma":[0.000008740309,0.0001941749,0.002230301,0.00001568788,0.00001616593,0.0003046238,0.00001967468,0.000703443,0.9899664,0.0001227396,0.006406175,0.0000118382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9005348,0.004478676,0.08715528,0.0005123342,0.0002428651,0.0002252508,0.001353356,0.0004763794,0.005021021],"genre_scores_gemma":[0.9276733,0.002188189,0.06462608,0.0001851907,0.00005210518,0.000456282,0.001292203,0.0001691984,0.003357417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001497207,"threshold_uncertainty_score":0.005008638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02912220254072767,"score_gpt":0.3223149373639773,"score_spread":0.2931927348232496,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}