{"id":"W4396887136","doi":"10.1073/pnas.2317616121","title":"Lipid-derived electrophiles inhibit the function of membrane channels during ferroptosis","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Lipid peroxidation; Programmed cell death; Cell biology; Chemistry; GPX4; Biochemistry; Glutathione; Function (biology); Biology; Oxidative stress; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001526056,0.0002349774,0.0002579388,0.00007886345,0.0000899246,0.0001878583,0.000150678,0.0002487233,0.0008827951],"category_scores_gemma":[0.0001721682,0.00008904339,0.0001531097,0.0000520062,0.0001952486,0.0002635055,0.0001560939,0.0003869014,0.0002315261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001710174,"about_ca_system_score_gemma":0.0001175787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001679161,"about_ca_topic_score_gemma":0.0003162909,"domain_scores_codex":[0.9999058,0.00001917467,0.000009841834,0.0000163003,0.00001879642,0.00002992086],"domain_scores_gemma":[0.9999044,0.00002343397,0.00002927688,0.00001331763,0.00001401674,0.00001542234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001054615,0.000009434845,0.00006584293,0.00001647485,0.000001903806,0.00002069409,0.000009059377,0.00002273257,0.9990844,0.00003009457,0.00001532838,0.000618603],"study_design_scores_gemma":[0.000004062623,0.0001577536,0.001183392,0.000001951228,0.000002566351,0.00006898538,0.00001008815,0.0002336417,0.9979512,0.00002375283,0.0003615634,0.000001107366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953134,0.001061027,0.002622211,0.0000840904,0.00001857488,0.00002069695,0.0001058255,0.000108686,0.000665448],"genre_scores_gemma":[0.9970273,0.000521777,0.001173294,0.00003668725,0.000005919165,0.0000185716,0.0001070257,0.0000100248,0.001099455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008827951,"threshold_uncertainty_score":0.002953291,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02282911926816786,"score_gpt":0.2759916773269981,"score_spread":0.2531625580588303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}