{"id":"W4396889096","doi":"10.1038/s41467-024-47619-4","title":"Disentangling oncogenic amplicons in esophageal adenocarcinoma","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute for Health and Care Research; Medical Research Council; Cambridge Trust; Department of Health and Social Care; Cancer Research UK; New York Genome Center","keywords":"Esophageal adenocarcinoma; Amplicon; Adenocarcinoma; Biology; Cancer research; Computational biology; Genetics; Cancer; Polymerase chain reaction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406346,0.0001751161,0.0002089666,0.0009806616,0.0001499929,0.0003727022,0.000130169,0.0002710176,0.0007461285],"category_scores_gemma":[0.0006451185,0.0001555009,0.0001882499,0.0004597676,0.0001793743,0.0001909859,0.0003324604,0.0001935159,0.0001880259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001503839,"about_ca_system_score_gemma":0.0001047617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007247004,"about_ca_topic_score_gemma":0.00235386,"domain_scores_codex":[0.9998067,0.00002531332,0.00001900112,0.0000682527,0.00005681643,0.00002398767],"domain_scores_gemma":[0.9996507,0.0001140282,0.00008204751,0.00005710348,0.00005337248,0.00004263845],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003230876,0.00002767513,0.1650292,0.0001156656,0.00008921244,0.0006387091,0.0003524973,0.001079354,0.8113333,0.0001936358,0.00006769329,0.02075],"study_design_scores_gemma":[0.000008353985,0.000231905,0.637187,0.000024623,0.0002010014,0.00508,0.0004698118,0.008009495,0.3442017,0.0006431819,0.003925711,0.00001735157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947805,0.0008698227,0.003569027,0.00001647929,0.000002845217,0.000009597152,0.0002328856,0.00004205076,0.0004768154],"genre_scores_gemma":[0.9948986,0.0002805867,0.003981659,0.00001653923,0.00000281705,0.000007633117,0.0004518761,0.00001756098,0.000342629],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009806616,"threshold_uncertainty_score":0.002496064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01334977117667756,"score_gpt":0.3046272188988569,"score_spread":0.2912774477221793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}