{"id":"W4396896062","doi":"10.1242/dev.202269","title":"Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish","year":2024,"lang":"en","type":"article","venue":"Development","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Moonshot Research and Development Program; Japan Society for the Promotion of Science; Institute of Genetics; Japan Science and Technology Agency; SENSHIN Medical Research Foundation; Korea Advanced Institute of Science and Technology; Uppsala Universitet; Takeda Science Foundation; Sumitomo Foundation; University of Melbourne; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Deutsche Forschungsgemeinschaft","keywords":"Biology; Zebrafish; Cell biology; Receptor tyrosine kinase; Lymphangiogenesis; Angiopoietin receptor; Angiopoietin; Signal transduction; Receptor Protein-Tyrosine Kinases; Receptor; Genetics; Cancer research; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008984617,0.0004102282,0.0002395281,0.0003439499,0.0003407347,0.0002535569,0.0002666525,0.0003484972,0.002790852],"category_scores_gemma":[0.0001095304,0.000319793,0.0003348648,0.0001104605,0.000310028,0.0002761882,0.0003822999,0.000852193,0.0007709008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008716933,"about_ca_system_score_gemma":0.0004323202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004901246,"about_ca_topic_score_gemma":0.007232397,"domain_scores_codex":[0.9998564,0.00001152263,0.000009671341,0.00003660478,0.00004414887,0.00004176543],"domain_scores_gemma":[0.9998848,0.00001130489,0.00004152325,0.000005590637,0.0000122365,0.00004449203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002226283,0.000003073048,0.0000973471,0.00001375605,0.000001280584,0.00004881243,0.000008990802,0.00005833881,0.9993174,0.00009848746,0.00003000417,0.0003001366],"study_design_scores_gemma":[0.00002865765,0.00007823489,0.01119072,0.00001520453,0.00002238195,0.0002600803,0.00005362175,0.002588245,0.982042,0.0001141183,0.003593383,0.00001328023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887658,0.001120173,0.005022132,0.0001605245,0.00004155713,0.00002855785,0.0007582825,0.0001454566,0.003957361],"genre_scores_gemma":[0.9847413,0.0007283173,0.00370393,0.000124577,0.000007848244,0.00005987037,0.0005939318,0.00009333037,0.009946856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004901246,"threshold_uncertainty_score":0.009745479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336657210694987,"score_gpt":0.2891369641172503,"score_spread":0.2557703920103004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}