{"id":"W4396896062","doi":"10.1242/dev.202269","title":"Angpt1 binding to Tie1 regulates the signaling required for lymphatic vessel development in zebrafish","year":2024,"lang":"en","type":"article","venue":"Development","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Moonshot Research and Development Program; Japan Society for the Promotion of Science; Institute of Genetics; Japan Science and Technology Agency; SENSHIN Medical Research Foundation; Korea Advanced Institute of Science and Technology; Uppsala Universitet; Takeda Science Foundation; Sumitomo Foundation; University of Melbourne; Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care; Deutsche Forschungsgemeinschaft","keywords":"Biology; Zebrafish; Cell biology; Receptor tyrosine kinase; Lymphangiogenesis; Angiopoietin receptor; Angiopoietin; Signal transduction; Receptor Protein-Tyrosine Kinases; Receptor; Genetics; Cancer research; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007165277,0.0002126389,0.000298934,0.0002861258,0.0001601885,0.0001158219,0.0001428477,0.00006092562,0.00005191379],"category_scores_gemma":[0.0001889872,0.0001447257,0.00006500574,0.0004919383,0.00002150965,0.00008499794,0.00006755157,0.00001730486,0.0001572994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006361182,"about_ca_system_score_gemma":0.001299431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004920545,"about_ca_topic_score_gemma":0.000007650808,"domain_scores_codex":[0.998196,0.00003149045,0.0005946071,0.0003849617,0.0003822841,0.0004106456],"domain_scores_gemma":[0.99923,0.0002668436,0.00004670387,0.000203063,0.0000706043,0.000182814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001371759,0.001393111,0.05428232,0.01368114,0.002173798,0.001075599,0.1737486,0.0003167308,0.1093302,0.005008257,0.09521397,0.5424045],"study_design_scores_gemma":[0.005219439,0.0002130997,0.1180706,0.01468551,0.0002712321,0.000127055,0.006525966,0.001195402,0.3358476,0.0007331498,0.5157107,0.001400197],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923679,0.001422809,0.001268189,0.002020254,0.0005442123,0.00154717,0.000004928005,0.0001534318,0.0006711035],"genre_scores_gemma":[0.9823072,0.000004463241,0.01286033,0.0009341904,0.0001382359,0.0007565244,0.00007152267,0.00004423736,0.002883326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5410042,"threshold_uncertainty_score":0.5901743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03336657210694987,"score_gpt":0.2891369641172503,"score_spread":0.2557703920103004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}