{"id":"W4396905428","doi":"10.21203/rs.3.rs-4361337/v1","title":"Azacytidine Treatment Affects Methylation Pattern of Genomic and Cell-Free DNA in Uveal Melanoma Cell Lines","year":2024,"lang":"en","type":"preprint","venue":"Research Square","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"","keywords":"DNA methylation; Melanoma; Methylation; Cancer research; Cell; DNA; Biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001252207,0.0001364763,0.0002062122,0.0001701605,0.0001616561,0.0001811799,0.000151439,0.0001848762,0.001606163],"category_scores_gemma":[0.0001583349,0.00008265922,0.0001425454,0.0001705591,0.0001008951,0.00007851759,0.0001055681,0.0002458172,0.0005100797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002424371,"about_ca_system_score_gemma":0.0001170888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00282825,"about_ca_topic_score_gemma":0.003260701,"domain_scores_codex":[0.9998878,0.00001854322,0.00001463519,0.00002963023,0.00003347942,0.00001579245],"domain_scores_gemma":[0.9999194,0.00002401349,0.00001188386,0.00001565396,0.00001712295,0.00001187225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008145345,0.00001634779,0.0005141109,0.00002584482,0.000004862651,0.00003955296,0.00002751568,0.00007445618,0.9971811,0.00004862078,0.00009511555,0.001891163],"study_design_scores_gemma":[0.000005600844,0.0001589766,0.008104926,0.000003249611,0.00001052384,0.000107553,0.00001933144,0.000542551,0.9885958,0.00002011135,0.002428231,0.000003132126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988161,0.002583841,0.003375554,0.00008891364,0.00003439384,0.00003778444,0.001734792,0.0001392385,0.003844562],"genre_scores_gemma":[0.9818001,0.00158599,0.005826307,0.00004992974,0.000008517908,0.00006381155,0.003249737,0.00003334711,0.007382122],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00282825,"threshold_uncertainty_score":0.005623579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03151863981699516,"score_gpt":0.3437464115134982,"score_spread":0.3122277716965031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}