{"id":"W4396905456","doi":"10.1038/s41418-024-01307-4","title":"Mutant p53 reactivation restricts the protumorigenic consequences of wild type p53 loss of heterozygosity in Li-Fraumeni syndrome patient-derived fibroblasts","year":2024,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Planning and Budgeting Committee of the Council for Higher Education of Israel; Israel Cancer Research Fund; Israel Science Foundation; Weizmann Institute of Science; Flight Attendant Medical Research Institute; Division of Chemistry; Council for Higher Education","keywords":"Loss of heterozygosity; Mutant; Allele; Wild type; Cancer research; Biology; Heterozygote advantage; Suppressor; Tumor suppressor gene; Mutant protein; Gene; Molecular biology; Genetics; Carcinogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001390068,0.0001996989,0.0001776169,0.000169882,0.0001087914,0.0002210207,0.0001227309,0.0001823325,0.0007130437],"category_scores_gemma":[0.0001605613,0.0001034715,0.0001339002,0.00008153557,0.0001473479,0.0001015795,0.00009678998,0.0003011175,0.0002414083],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009513681,"about_ca_system_score_gemma":0.0001309535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003714524,"about_ca_topic_score_gemma":0.0005829281,"domain_scores_codex":[0.9998949,0.00002710681,0.00001206799,0.00002101485,0.00002226858,0.00002272295],"domain_scores_gemma":[0.9998771,0.00005234632,0.00001656801,0.00002081939,0.000007422532,0.00002571479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005699315,0.00002267329,0.0001634872,0.000008105734,0.000001761967,0.0001234094,0.000009898098,0.00003008528,0.9989198,0.0000317967,0.00001192971,0.0006199393],"study_design_scores_gemma":[0.00002208335,0.0006034527,0.004488138,0.000003432605,0.00001277908,0.001022928,0.00002794485,0.0005537216,0.9921247,0.00003343132,0.001103554,0.000003773126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978247,0.0005505113,0.0007100142,0.00002548405,0.000007943376,0.00001650066,0.00008343379,0.00002435996,0.0007570715],"genre_scores_gemma":[0.998484,0.0002559704,0.0005424915,0.0000151923,0.000004016398,0.00001500995,0.0001052345,0.000005222105,0.0005728492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007130437,"threshold_uncertainty_score":0.002385378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132875265940787,"score_gpt":0.2280363576514984,"score_spread":0.2147488310574197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}