{"id":"W4396913568","doi":"10.1093/ced/llae185","title":"Loss-of-function <i>FLG</i> mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London","year":2024,"lang":"en","type":"article","venue":"Clinical and Experimental Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Filaggrin; Family history; Atopic dermatitis; Medicine; Cohort; Exact test; Context (archaeology); Ichthyosis vulgaris; Dermatology; Internal medicine; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610559,0.0002876422,0.000408005,0.0007735681,0.0004649947,0.0006972692,0.000315283,0.0003862898,0.002718898],"category_scores_gemma":[0.001125146,0.0002718592,0.0002785855,0.0007330124,0.0003843721,0.000296716,0.0003779666,0.0003603612,0.0004810982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003467994,"about_ca_system_score_gemma":0.000211046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009814969,"about_ca_topic_score_gemma":0.007475923,"domain_scores_codex":[0.9997448,0.00003552594,0.00003497779,0.00008462306,0.00005033297,0.00004975136],"domain_scores_gemma":[0.9989917,0.0001412218,0.0005192445,0.00006679157,0.00009204107,0.0001890272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009113306,0.000009380055,0.9979922,0.000006564047,0.00001611424,0.0004984172,0.0001478982,0.00001204038,0.0007309878,0.000008849044,0.00005291255,0.0004335092],"study_design_scores_gemma":[0.000006478183,0.00005957147,0.997138,0.000005461351,0.00001514766,0.002197324,0.0003259011,0.00003542911,0.00007042857,0.000007391399,0.0001359374,0.000002905551],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994113,0.0001050007,0.00001728708,0.00002064869,0.000001838111,0.000003972535,0.0001161778,0.000001647901,0.0003221413],"genre_scores_gemma":[0.9996692,0.00005694378,0.00001781239,0.0000132783,0.000003107923,0.00000370136,0.0001157991,0.000001521024,0.0001186449],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009814969,"threshold_uncertainty_score":0.01951569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02704216031427488,"score_gpt":0.3100593066462311,"score_spread":0.2830171463319562,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}