{"id":"W4396915738","doi":"10.1101/2024.05.15.594279","title":"Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Horizon 2020 Framework Programme; Université de Montpellier; Centre National de la Recherche Scientifique; Killam Trusts","keywords":"Pseudomonas aeruginosa; Microbiology; Antibiotics; Biofilm; Cystic fibrosis; Intracellular parasite; Biology; Zebrafish; In vivo; Bacteria; Innate immune system; Immunity; Intracellular; Immune system; Antibiotic resistance; Chronic infection; Multidrug tolerance; Host (biology); Immunology; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001800953,0.0004035012,0.0003302204,0.0002384291,0.0001887654,0.0002508639,0.0002351701,0.0005679898,0.0009621511],"category_scores_gemma":[0.00009548682,0.0001702955,0.0002656699,0.0001097322,0.0002633096,0.0003087655,0.0004075203,0.0008723805,0.0002541702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002720454,"about_ca_system_score_gemma":0.0002345823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001221617,"about_ca_topic_score_gemma":0.001625738,"domain_scores_codex":[0.9998186,0.00001678117,0.00001346485,0.00004522309,0.00006937068,0.00003657586],"domain_scores_gemma":[0.9998922,0.00001338056,0.00003134631,0.00001714245,0.00001780688,0.0000280911],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001760359,0.00001192757,0.0000544024,0.00001455754,0.000001217126,0.00002572303,0.00001103352,0.00002923591,0.9994272,0.00004526039,0.00002806829,0.0003337539],"study_design_scores_gemma":[0.00001230481,0.0003975907,0.002383999,0.00001402687,0.00001222891,0.0001860697,0.00003468,0.001606068,0.9934914,0.00008359184,0.001769326,0.000008750149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804239,0.001310183,0.0147923,0.000328824,0.00009324076,0.0001004855,0.0005745906,0.0001769304,0.002199504],"genre_scores_gemma":[0.9756677,0.00110792,0.01522059,0.0001530438,0.00001713662,0.000139182,0.0004838856,0.00006143928,0.007149299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001221617,"threshold_uncertainty_score":0.003218651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0112783228646215,"score_gpt":0.2180474435626949,"score_spread":0.2067691206980734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}