{"id":"W4396917534","doi":"10.1038/s41598-024-61493-6","title":"Cholesterol accumulation impairs HIF-1α-dependent immunometabolic reprogramming of LPS-stimulated macrophages by upregulating the NRF2 pathway","year":2024,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"Canadian Institutes of Health Research; Korea Research Institute of Bioscience and Biotechnology; University of Toronto; University of Dundee","keywords":"Transactivation; Cholesterol; Transcription factor; Stimulation; KEAP1; Reprogramming; Cell biology; Chemistry; Lipid metabolism; Oxidative stress; Glycolysis; Signal transduction; Downregulation and upregulation; Oxidative phosphorylation; Biochemistry; Metabolism; Biology; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002510135,0.0004116301,0.0004796647,0.0002848203,0.000191967,0.0002338213,0.0001988732,0.0003325367,0.001011224],"category_scores_gemma":[0.0001178962,0.0001743941,0.0003979006,0.0001720663,0.0002905431,0.0002780214,0.0002654241,0.0005951554,0.0003508623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002238518,"about_ca_system_score_gemma":0.0002845567,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005777978,"about_ca_topic_score_gemma":0.0006188488,"domain_scores_codex":[0.999767,0.00004290694,0.00003356165,0.00004152124,0.00003806052,0.00007689772],"domain_scores_gemma":[0.9998651,0.00001028894,0.00004505334,0.00001721932,0.0000216097,0.00004083247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004700679,0.00004780577,0.0001345492,0.00004578377,0.00000510403,0.0000458619,0.00001526969,0.00002682011,0.9986011,0.00003737005,0.00002889932,0.0005413597],"study_design_scores_gemma":[0.00003240299,0.0004211068,0.002689063,0.000008673529,0.0000171211,0.0001104879,0.00004074526,0.0005148266,0.9947425,0.0000703672,0.001346501,0.000006291055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947055,0.001522207,0.00224492,0.0002055064,0.00004862502,0.00003491657,0.0003915714,0.00008115049,0.0007656096],"genre_scores_gemma":[0.99431,0.0009408224,0.001647585,0.0001430541,0.0000178085,0.0000842443,0.000543507,0.00002103352,0.002292024],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001011224,"threshold_uncertainty_score":0.003382862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01546062917182307,"score_gpt":0.2686149695085011,"score_spread":0.253154340336678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}