{"id":"W4396922010","doi":"10.1016/j.chom.2024.04.016","title":"Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans","year":2024,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Horizon 2020; Vilnius University; H. Lundbeck A/S; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Novo Nordisk; Institut Pasteur; Lundbeckfonden; Eidgenössische Technische Hochschule Zürich; Agence Nationale de la Recherche; European Regional Development Fund; European Commission; Deutsche Forschungsgemeinschaft; Infrastructures en Biologie Santé et Agronomie; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Lietuvos Mokslo Taryba; Oxford Nanopore Technologies; Villum Fonden; University of Otago","keywords":"Plasmid; CRISPR; Biology; Horizontal gene transfer; Genetics; Gene; Ribonucleoprotein; Cas9; Klebsiella pneumoniae; Computational biology; RNA; Escherichia coli; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005354283,0.001066527,0.0007904329,0.000810721,0.0006447987,0.00155295,0.001038591,0.001032408,0.005400488],"category_scores_gemma":[0.0007946963,0.0007282215,0.0008008044,0.0006768355,0.0009706268,0.0006179514,0.001330834,0.002591297,0.004365113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001019035,"about_ca_system_score_gemma":0.0009282014,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001290052,"about_ca_topic_score_gemma":0.003148281,"domain_scores_codex":[0.9990995,0.0001110101,0.0000969876,0.0002091951,0.0003064325,0.0001769092],"domain_scores_gemma":[0.9986935,0.0002771861,0.0004376708,0.0002619674,0.0001236195,0.0002060827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007931055,0.00005255031,0.0003532952,0.00003739369,0.00001600965,0.00008741401,0.00003822096,0.0001572484,0.9950203,0.001177755,0.0002714533,0.002709026],"study_design_scores_gemma":[0.00001661918,0.00006538857,0.001004375,0.000006129722,0.00001601455,0.0003454517,0.00003790934,0.002028068,0.9912289,0.000305147,0.004928082,0.00001782087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7968445,0.0006763818,0.1687368,0.0004123377,0.0004859758,0.0005667378,0.002265944,0.005448428,0.02456271],"genre_scores_gemma":[0.9323169,0.0002185461,0.04702311,0.0002208921,0.00002058577,0.0001419627,0.001491025,0.0008752014,0.01769185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005400488,"threshold_uncertainty_score":0.01806641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005535740566083342,"score_gpt":0.2683810761212437,"score_spread":0.2628453355551603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}