{"id":"W4396922010","doi":"10.1016/j.chom.2024.04.016","title":"Type IV-A3 CRISPR-Cas systems drive inter-plasmid conflicts by acquiring spacers in trans","year":2024,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"Horizon 2020; Vilnius University; H. Lundbeck A/S; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Novo Nordisk; Institut Pasteur; Lundbeckfonden; Eidgenössische Technische Hochschule Zürich; Agence Nationale de la Recherche; European Regional Development Fund; European Commission; Deutsche Forschungsgemeinschaft; Infrastructures en Biologie Santé et Agronomie; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Lietuvos Mokslo Taryba; Oxford Nanopore Technologies; Villum Fonden; University of Otago","keywords":"Plasmid; CRISPR; Biology; Horizontal gene transfer; Genetics; Gene; Ribonucleoprotein; Cas9; Klebsiella pneumoniae; Computational biology; RNA; Escherichia coli; Genome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001036096,0.0002192559,0.0001774207,0.00007728392,0.00002973459,0.00008181328,0.0001731093,0.0001823752,0.00005110721],"category_scores_gemma":[0.000008899162,0.0002292278,0.00008095425,0.0001396361,0.00004615389,0.000004606376,0.00006868022,0.0001625199,0.00005394467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004090797,"about_ca_system_score_gemma":0.00004135622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007752492,"about_ca_topic_score_gemma":0.00005245961,"domain_scores_codex":[0.9989217,0.00002372832,0.000221351,0.0004249962,0.00006776395,0.0003404747],"domain_scores_gemma":[0.9995845,0.00001428388,0.00002283034,0.0002539278,0.00003359046,0.00009088392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001927908,0.00002225601,0.0001622194,0.0002043519,0.00003264565,0.00002455778,0.0005442437,0.0004305437,0.9713806,0.00000549919,0.0269199,0.0002538992],"study_design_scores_gemma":[0.0002297626,0.00008842479,0.00004761718,0.00009540279,0.00001612578,0.00001880242,0.0001940887,0.000778234,0.6311408,7.134649e-7,0.3671913,0.0001986746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9060046,0.05193494,0.03345088,0.0002187544,0.002057569,0.0004326095,0.00008748171,0.00007734942,0.005735782],"genre_scores_gemma":[0.9935583,0.0009403159,0.0001005188,0.00009524003,0.0001475888,0.00001234604,0.00009079113,0.00005449685,0.005000331],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3402714,"threshold_uncertainty_score":0.9347638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005535740566083342,"score_gpt":0.2683810761212437,"score_spread":0.2628453355551603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}