{"id":"W4396922130","doi":"10.1093/eurheartj/ehae251","title":"Brugada syndrome in Japan and Europe: a genome-wide association study reveals shared genetic architecture and new risk loci","year":2024,"lang":"en","type":"review","venue":"European Heart Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Danish Cardiovascular Academy; Moonshot Research and Development Program; Japan Society for the Promotion of Science; Horizon 2020 Framework Programme; Novo Nordisk Fonden; Centre National de la Recherche Scientifique; Novo Nordisk; Agence Nationale de Recherches sur le Sida et les Hépatites Virales; Fédération Française de Cardiologie; Institut Français de Bioinformatique; Hartstichting; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; Research Center for Infectious Diseases and Tropical Medicine, Tabriz University of Medical Sciences; European Commission; Ministry of Education; Japan Agency for Medical Research and Development; Takeda Science Foundation; CHIST-ERA; Conseil Régional des Pays de la Loire; National Research Council of Thailand; Agence Nationale de la Recherche; Hjerteforeningen","keywords":"Medicine; Brugada syndrome; Genetic architecture; Genome-wide association study; Association (psychology); Genetic association; Genetics; Evolutionary biology; Single-nucleotide polymorphism; Environmental health; Gene; Internal medicine; Genotype; Quantitative trait locus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008046945,0.0006269221,0.0008647565,0.001253885,0.0007396592,0.001023452,0.0003925732,0.0006011468,0.001137536],"category_scores_gemma":[0.001200909,0.0003502774,0.0009628081,0.00185772,0.000471905,0.0003451953,0.0009826743,0.0003998636,0.0001121363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002843897,"about_ca_system_score_gemma":0.0004043175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009648072,"about_ca_topic_score_gemma":0.01130142,"domain_scores_codex":[0.9993273,0.0001211894,0.00009942015,0.0002966654,0.0000810092,0.00007443045],"domain_scores_gemma":[0.9993848,0.0001089117,0.0001959271,0.00007261883,0.00008337701,0.0001543434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0004168452,0.00003488033,0.9894912,0.00004284502,0.0009099558,0.00091588,0.0004371461,0.00007732637,0.002909964,0.0000623361,0.0001247498,0.004576746],"study_design_scores_gemma":[0.00003516635,0.00003420224,0.9981706,0.00001091649,0.0003816884,0.0006905295,0.0002264565,0.0001333485,0.00006039654,0.00005087538,0.000199402,0.000006358067],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9983636,0.001086145,0.0001693447,0.00005934074,0.000008184724,0.000003877755,0.00008368578,0.00000562486,0.0002201457],"genre_scores_gemma":[0.9989229,0.0004575921,0.0002292474,0.00004542015,0.00001528486,0.00000647259,0.0002228355,0.000005472451,0.0000949555],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.009648072,"threshold_uncertainty_score":0.01918387,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02997246543504219,"score_gpt":0.3030608993304675,"score_spread":0.2730884338954253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}