{"id":"W4396922230","doi":"10.26508/lsa.202301956","title":"Defects in integrin complex formation promote<i>CHKB</i>-mediated muscular dystrophy","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Sarcolemma; Vinculin; Muscular dystrophy; Cell biology; Integrin-linked kinase; Dystrophin; ITGA7; Myocyte; Dysferlin; Biology; Integrin; Focal adhesion; Caveolin 3; Utrophin; Membrane protein; Kinase; Protein kinase A; Cell; Biochemistry; Membrane; Signal transduction; Genetics; Caveolae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002898239,0.0001175593,0.00009926783,0.0000653384,0.00008932731,0.00005377039,0.0003247685,0.00007929381,0.00002205728],"category_scores_gemma":[0.0002060511,0.0001039625,0.00004940035,0.0005512694,0.0003387977,0.00003536975,0.000089817,0.0001237648,0.00009003004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002140782,"about_ca_system_score_gemma":0.0001860652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001634255,"about_ca_topic_score_gemma":0.0000466653,"domain_scores_codex":[0.9988979,0.00003512385,0.0001688475,0.0004205563,0.0001601471,0.0003174241],"domain_scores_gemma":[0.9995764,0.00001092457,0.00003243356,0.0002412941,0.00004515504,0.00009373294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003174309,0.0000363404,0.0006165642,0.0000600725,0.000005468746,0.000005641405,0.000124491,0.0003521365,0.995699,0.0006080649,0.0008909236,0.001569573],"study_design_scores_gemma":[0.002553427,0.001572852,0.2093048,0.0005988063,0.00003360129,0.00003854731,0.0008823212,0.0936437,0.4917132,0.004601946,0.1931987,0.001858051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952474,0.0012155,0.001675551,0.0003550405,0.0002191664,0.0002061425,0.000008313287,0.00003253033,0.001040386],"genre_scores_gemma":[0.9985546,0.0001679683,0.000398633,0.000643774,0.00007124802,0.00003347304,0.00006665942,0.000008118946,0.00005552165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5039858,"threshold_uncertainty_score":0.4239467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506818259946081,"score_gpt":0.2709175400555114,"score_spread":0.2558493574560506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}