{"id":"W4396922230","doi":"10.26508/lsa.202301956","title":"Defects in integrin complex formation promote<i>CHKB</i>-mediated muscular dystrophy","year":2024,"lang":"en","type":"article","venue":"Life Science Alliance","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Canadian Institutes of Health Research; McMaster University","keywords":"Sarcolemma; Vinculin; Muscular dystrophy; Cell biology; Integrin-linked kinase; Dystrophin; ITGA7; Myocyte; Dysferlin; Biology; Integrin; Focal adhesion; Caveolin 3; Utrophin; Membrane protein; Kinase; Protein kinase A; Cell; Biochemistry; Membrane; Signal transduction; Genetics; Caveolae","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132483,0.0004974508,0.0002104743,0.0003619461,0.0002738681,0.000376832,0.0002218908,0.0004718157,0.003133018],"category_scores_gemma":[0.000179623,0.0002398723,0.0002568318,0.0001493725,0.0003238722,0.0001636952,0.0004312274,0.0006857302,0.0007981677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004195567,"about_ca_system_score_gemma":0.0001625343,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001695383,"about_ca_topic_score_gemma":0.001979255,"domain_scores_codex":[0.9997517,0.00003942168,0.0000277314,0.00005754542,0.00005846874,0.00006494641],"domain_scores_gemma":[0.9998285,0.00001940138,0.00006633776,0.00001472863,0.00001383901,0.00005720947],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005685901,0.00001636979,0.0002774034,0.0000123949,0.000004765162,0.0001587042,0.000009863659,0.00003890253,0.9989496,0.00008347426,0.00006225599,0.0003295683],"study_design_scores_gemma":[0.00003970978,0.0002329972,0.03123354,0.00001944793,0.0000308528,0.002859684,0.00008666534,0.001249998,0.9602171,0.00008865779,0.003931993,0.000009273565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952991,0.0005203852,0.001457663,0.0001052672,0.00002601721,0.00001798939,0.000332833,0.0001066963,0.002134006],"genre_scores_gemma":[0.9950235,0.0002618104,0.0007572197,0.00005637693,0.000005656442,0.0000214444,0.0003089047,0.00003618758,0.003528973],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003133018,"threshold_uncertainty_score":0.010481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01506818259946081,"score_gpt":0.2709175400555114,"score_spread":0.2558493574560506,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}