{"id":"W4396931896","doi":"10.1186/s13058-024-01818-5","title":"Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer","year":2024,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Oncolytic virus; Vesicular stomatitis virus; Immunotherapy; Medicine; Metastatic breast cancer; Virotherapy; Cancer research; Immune system; Breast cancer; Cancer; Adoptive cell transfer; Immunology; Triple-negative breast cancer; T cell; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00104162,0.0004382289,0.0004287478,0.0003291648,0.000320444,0.000336677,0.0007646286,0.0001545012,0.001906858],"category_scores_gemma":[0.000009507335,0.0003393428,0.0002260747,0.0009049919,0.0004866023,0.00003089819,0.0001920194,0.0008040974,0.0001451045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003419525,"about_ca_system_score_gemma":0.001692218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00256829,"about_ca_topic_score_gemma":0.003166252,"domain_scores_codex":[0.9953574,0.0006705123,0.0003536654,0.0009973947,0.001342387,0.001278629],"domain_scores_gemma":[0.9980923,0.00009106969,0.00006188637,0.000860535,0.0005939063,0.0003002846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01514201,0.0002512637,0.0004117703,0.0002274338,0.001235265,0.0001527242,0.0001288773,0.0002483331,0.9278505,0.00004863057,0.007775264,0.04652788],"study_design_scores_gemma":[0.01731858,0.008426717,0.01741535,0.0009510365,0.0002343812,0.001176244,0.0003643652,0.003389266,0.8700235,0.0002706658,0.0780137,0.002416169],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.932659,0.05912843,0.00007346147,0.004663841,0.0004743804,0.00144763,0.001105368,0.00008994359,0.0003579676],"genre_scores_gemma":[0.9856142,0.007045355,0.00006195392,0.0003950413,0.0005584179,0.001345426,0.0001407765,0.0001908746,0.004647982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07023843,"threshold_uncertainty_score":0.9999059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651122599620147,"score_gpt":0.3379558663600477,"score_spread":0.3214446403638462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}