{"id":"W4396931896","doi":"10.1186/s13058-024-01818-5","title":"Fusogenic vesicular stomatitis virus combined with natural killer T cell immunotherapy controls metastatic breast cancer","year":2024,"lang":"en","type":"article","venue":"Breast Cancer Research","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Beatrice Hunter Cancer Research Institute; Dalhousie University","funders":"Canadian Institutes of Health Research; Dalhousie University; Dalhousie Medical Research Foundation; Beatrice Hunter Cancer Research Institute; Cancer Research Institute","keywords":"Oncolytic virus; Vesicular stomatitis virus; Immunotherapy; Medicine; Metastatic breast cancer; Virotherapy; Cancer research; Immune system; Breast cancer; Cancer; Adoptive cell transfer; Immunology; Triple-negative breast cancer; T cell; Virus; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176538,0.0003738215,0.000442076,0.0002167909,0.0001011551,0.0002474423,0.0002373294,0.0002753469,0.000903613],"category_scores_gemma":[0.00009667569,0.00009002197,0.0002251921,0.0001382779,0.0002737324,0.0001644942,0.0001478287,0.0005359054,0.0002172161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003047838,"about_ca_system_score_gemma":0.0002808376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005543256,"about_ca_topic_score_gemma":0.0007149029,"domain_scores_codex":[0.9998701,0.0000147844,0.000008654188,0.00002959821,0.0000303017,0.00004652439],"domain_scores_gemma":[0.9999397,0.000009703042,0.00001875038,0.000007647228,0.000006207992,0.00001809268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009215508,0.000546687,0.0003029666,0.00008773843,0.00001714134,0.00006369741,0.00002546081,0.0002855014,0.9899616,0.0001317365,0.0001555734,0.007500373],"study_design_scores_gemma":[0.0003164118,0.01182891,0.003917825,0.00001308913,0.00008987798,0.0006188733,0.00003815609,0.002095213,0.9761367,0.0001184709,0.004818699,0.00000781352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99665,0.001275865,0.0007446673,0.00005949957,0.00005781494,0.00007248355,0.000097509,0.00008936297,0.0009527034],"genre_scores_gemma":[0.9973917,0.0006806178,0.0006397517,0.00002344004,0.00002108881,0.00005985613,0.0001733211,0.000009243424,0.001000991],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000903613,"threshold_uncertainty_score":0.00302285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01651122599620147,"score_gpt":0.3379558663600477,"score_spread":0.3214446403638462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}