{"id":"W4396935811","doi":"10.1016/j.ocarto.2024.100490","title":"Cobalt ions induce a cellular senescence secretory phenotype in human synovial fibroblast-like cells that may be an early event in the development of adverse local tissue reactions to hip implants","year":2024,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage Open","topic":"Orthopaedic implants and arthroplasty","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Osteolysis; Synovial membrane; Arthroplasty; Medicine; Osteoarthritis; Chemistry; Inflammation; Rheumatoid arthritis; Adverse effect; Pathology; Cancer research; Immunology; Surgery; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001442674,0.000254899,0.000278751,0.0002080003,0.0001525541,0.0002853606,0.00007313709,0.000218938,0.001442114],"category_scores_gemma":[0.0001936774,0.0001187764,0.0002991659,0.0001517777,0.0001516229,0.00008937183,0.0001997657,0.0002280859,0.0003576105],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001803247,"about_ca_system_score_gemma":0.0002046471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007906111,"about_ca_topic_score_gemma":0.00113147,"domain_scores_codex":[0.9997861,0.00003120811,0.00003080643,0.00003601066,0.0000703472,0.00004570749],"domain_scores_gemma":[0.9998013,0.00003389702,0.00005112731,0.0000258598,0.00005781049,0.00003001346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002102592,0.00002594591,0.0007442671,0.00007728028,0.000008033697,0.000146171,0.00003621815,0.00001861418,0.997557,0.00001312932,0.00003579367,0.001127187],"study_design_scores_gemma":[0.00005235931,0.002028533,0.03584229,0.00002106798,0.00004109279,0.001159564,0.0001884684,0.000291527,0.9571434,0.00006094843,0.003161603,0.000009173747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906601,0.004902158,0.002142653,0.0001125199,0.00008438774,0.00005492587,0.0002640442,0.00005466255,0.001724488],"genre_scores_gemma":[0.9953472,0.001031799,0.0008346768,0.00008845694,0.00002187985,0.00003771489,0.0002445414,0.000008344715,0.002385505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001442114,"threshold_uncertainty_score":0.00482434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02609609279743833,"score_gpt":0.2921526501238288,"score_spread":0.2660565573263904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}