{"id":"W4396938654","doi":"10.1136/gutjnl-2024-332325","title":"Beyond traditional subtyping: a multilayered genomic perspective on colorectal cancer","year":2024,"lang":"en","type":"letter","venue":"Gut","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Subtyping; Colorectal cancer; Perspective (graphical); Computational biology; Medicine; Oncology; Internal medicine; Computer science; Cancer; Biology; Programming language; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000359619,0.0004264894,0.0006140954,0.0002097128,0.0001261648,0.00003884515,0.00008842768,0.0003788756,0.0009288373],"category_scores_gemma":[0.0000319038,0.0003340998,0.0003486497,0.0001365184,0.0001309415,0.00002325068,0.00004566101,0.001291851,0.0003903737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002706764,"about_ca_system_score_gemma":0.0004631091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005555761,"about_ca_topic_score_gemma":0.0002153291,"domain_scores_codex":[0.9982809,0.00002625966,0.0002165178,0.0006984543,0.0003969385,0.0003809374],"domain_scores_gemma":[0.9994042,0.0001423503,0.00007642261,0.0001748717,0.0001315829,0.00007060258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005649251,0.0001019885,0.0001428098,0.0001342911,0.001676942,0.001765151,0.001408958,0.000003021189,0.000233602,0.0003112458,0.9928688,0.0007882622],"study_design_scores_gemma":[0.00268377,0.002142815,0.03125187,0.0009295894,0.001759561,0.0002206191,0.0004610573,0.0001012701,0.000221738,0.002513804,0.9569525,0.0007614199],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.07318757,0.0102607,4.655265e-7,0.8234074,0.002745441,0.001166075,0.001872811,0.0001902732,0.08716932],"genre_scores_gemma":[0.3665119,0.0009315691,0.00008559572,0.5778177,0.0189849,0.001461097,0.0008269941,0.0002181715,0.03316208],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.2933243,"threshold_uncertainty_score":0.9999844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04108605186470986,"score_gpt":0.3081101754415621,"score_spread":0.2670241235768522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}