{"id":"W4396950446","doi":"10.1073/pnas.2313207121","title":"Hypothalamic vasopressin sex differentiation is observed by embryonic day 15 in mice and is disrupted by the xenoestrogen bisphenol A","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Neuroendocrine regulation and behavior","field":"Psychology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"Canadian Institutes of Health Research; University of Calgary; Cumming School of Medicine, University of Calgary; Alberta Children's Hospital Research Institute; Natural Sciences and Engineering Research Council of Canada; Hotchkiss Brain Institute, University of Calgary","keywords":"Xenoestrogen; Sexual differentiation; Vasopressin; Bisphenol A; Endocrinology; Embryonic stem cell; Internal medicine; Biology; Andrology; Chemistry; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002362966,0.0007819926,0.0004621566,0.001088038,0.0003871017,0.0006701347,0.000582375,0.0007483959,0.005461276],"category_scores_gemma":[0.0002012763,0.0006946387,0.0006741584,0.0003543573,0.0008494792,0.0004191705,0.0007552818,0.001739728,0.001661725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005516026,"about_ca_system_score_gemma":0.0004001653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009061555,"about_ca_topic_score_gemma":0.002017716,"domain_scores_codex":[0.9993696,0.00005057791,0.00006620981,0.0001962347,0.000183298,0.0001340151],"domain_scores_gemma":[0.999406,0.00003304887,0.0003082846,0.00004176287,0.00003280138,0.0001781599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002752116,0.0000388693,0.0009118217,0.00004133207,0.00001531249,0.0002013451,0.00006087363,0.00003549339,0.9952167,0.0003092674,0.0001548718,0.002738885],"study_design_scores_gemma":[0.00006620811,0.0004482522,0.04989262,0.00005078977,0.00003987037,0.001034891,0.0001527027,0.0004236384,0.9284358,0.0003280991,0.01910003,0.00002715256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9645427,0.004937572,0.01121277,0.0004753174,0.0003398588,0.000177228,0.009166344,0.0009625508,0.008185631],"genre_scores_gemma":[0.9435222,0.004043358,0.007650536,0.0005499011,0.00006511969,0.0004768347,0.005481787,0.0005742719,0.03763586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005461276,"threshold_uncertainty_score":0.01826978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05658907294417039,"score_gpt":0.3370453529298345,"score_spread":0.2804562799856641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}