{"id":"W4396950498","doi":"10.1073/pnas.2318874121","title":"Essential role of N-terminal SAM regions in STIM1 multimerization and function","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"NHLBI Division of Intramural Research; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Dental and Craniofacial Research; Austrian Science Fund; Grantová Agentura České Republiky","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Transmembrane domain; Biophysics; Cell biology; Mutant; Transmembrane protein; Chemistry; HEK 293 cells; Coiled coil; C-terminus; Biology; Biochemistry; Membrane; Receptor; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003849219,0.00005112953,0.00007704397,0.0002116601,0.00008458114,0.00002003637,0.0002020486,0.00004827616,0.000009840199],"category_scores_gemma":[0.0002907264,0.00003377377,0.0000322857,0.0007979564,0.000605871,0.0004060371,0.00006265489,0.00009161451,5.098491e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001005897,"about_ca_system_score_gemma":0.00002130706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000606338,"about_ca_topic_score_gemma":5.319498e-8,"domain_scores_codex":[0.9989941,0.000006241933,0.0002035066,0.0001902072,0.0005289447,0.00007696589],"domain_scores_gemma":[0.9996918,0.00009396891,0.0001398539,0.000002894158,0.00005629763,0.0000151701],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000009719922,0.00002187069,0.0004005122,0.0000513048,0.000001239137,4.949819e-9,0.0002837199,0.0001374567,0.9579895,0.04005703,0.00006047562,0.0009871844],"study_design_scores_gemma":[0.00007040869,0.0000380293,0.005547586,0.0001332858,0.000005671193,0.000008562171,0.0001905193,0.02701338,0.9403183,0.02651061,0.0001229804,0.00004067585],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976557,0.0001128903,0.000006934145,0.0009513381,0.00006777058,0.0001019288,0.000007606235,0.000008758169,0.001087077],"genre_scores_gemma":[0.9996108,0.00006030865,0.0001299785,0.0000375117,0.00005703156,0.00000359384,6.136526e-8,0.000002368436,0.0000983924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02687592,"threshold_uncertainty_score":0.2232357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664572897754262,"score_gpt":0.3061627900970429,"score_spread":0.2695170611195004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}