{"id":"W4396950498","doi":"10.1073/pnas.2318874121","title":"Essential role of N-terminal SAM regions in STIM1 multimerization and function","year":2024,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion Channels and Receptors","field":"Neuroscience","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"NHLBI Division of Intramural Research; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; National Institute of Dental and Craniofacial Research; Austrian Science Fund; Grantová Agentura České Republiky","keywords":"STIM1; ORAI1; Endoplasmic reticulum; Transmembrane domain; Biophysics; Cell biology; Mutant; Transmembrane protein; Chemistry; HEK 293 cells; Coiled coil; C-terminus; Biology; Biochemistry; Membrane; Receptor; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008093383,0.0002967771,0.0001474326,0.00005896372,0.0001512537,0.0001546263,0.000143308,0.0001691622,0.0007423101],"category_scores_gemma":[0.0001255233,0.000109708,0.0001650085,0.00005490487,0.000197666,0.0001450552,0.0001868518,0.0002334473,0.0001803698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002034351,"about_ca_system_score_gemma":0.0002431021,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958974,"about_ca_topic_score_gemma":0.0005207041,"domain_scores_codex":[0.9999655,0.000007437403,0.000003265653,0.000006479352,0.000008980071,0.000008353768],"domain_scores_gemma":[0.9999405,0.00001098271,0.00002220271,0.000004176105,0.000005244101,0.00001691114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003420235,0.00005072446,0.001529084,0.00006049972,0.00001669881,0.0002005755,0.0000367617,0.01207038,0.9825106,0.0009351356,0.00005763698,0.002189893],"study_design_scores_gemma":[0.0001153222,0.0005482969,0.01278798,0.00003225234,0.00005284209,0.000454721,0.0001254369,0.1426289,0.8385752,0.0009487328,0.003693251,0.00003698927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950063,0.0001464626,0.004162082,0.00003175309,0.000008251765,0.00001150323,0.00006071675,0.00004105383,0.0005317543],"genre_scores_gemma":[0.9978295,0.00009137057,0.001789152,0.00001081221,0.000001395705,0.00001075331,0.00006946534,0.00001095015,0.0001866674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007423101,"threshold_uncertainty_score":0.002483308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03664572897754262,"score_gpt":0.3061627900970429,"score_spread":0.2695170611195004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}